DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B1 and ugt5c3

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001122186.1	Gene:	ugt5c3 / 563413	ZFINID:	ZDB-GENE-050419-23	Length:	531	Species:	Danio rerio

Alignment Length:	516	Identity:	132/516 - (25%)
Similarity:	233/516 - (45%)	Gaps:	84/516 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 MQPLVRTLATRGHNVTLITPIG---MPNDIEGVRHIRVAQLNERIKEMLESDQVLDFMIN----- 97
            |..|::.|..:||::.:|....   :....:....|.:.|.....:|.:  |.::..:||
Zfish    43 MDILIKALHGKGHSIDVIRNTNSWYVKEKSDYYNSITIPQSKGMDEEFV--DDMISKVINHERGK 105

  Fly    98 -KWTESALTAKALFNA--------------SNDILSDPGVQRMLHDKSESFDLIIMEPSSLDALY 147
             .|..   |.|..|::              :..|.....:.:.|.:|  .:||::.:|     ::
Zfish   106 SSWLS---TVKLFFDSVIDNYEMTKMVCDITTSIFESEEILKTLQEK--QYDLMLTDP-----VW 160

  Fly   148 G----------LVEFYNATLMGLSSIRINWHT-----YELAGNPAPSIYEPISPVGFSLETSLFS 197
            |          |...||          :.|.|     :.:|  |:|..|.||:..|.:...|.|.
Zfish   161 GMGIILAHKLKLPMVYN----------VRWTTTVDGHFNIA--PSPMSYIPITGSGNTDRMSFFQ 213

  Fly   198 RVYNWIHIMEEKLVNYLILRPAQLHLFQKFFGYSAQKMNELRSRFSLMLINSHYSMGKVRANAPN 262
            ||.|.|......:.......|....:..|:|..... ..:|.....:.|:...:.....|...||
Zfish   214 RVKNIIFYFTNDIKYSRFSLPQYQAICDKYFDPPVD-FYQLLQGADIWLMRVDFVFEFPRPTMPN 277

  Fly   263 IIEVGGLHLSEPPEPSDEELQKFLDKA-DHGVIYFSMGNDILIKFLPENIQELLLQTFATLNESI 326
            ||..||...: |.:|...:|:.|:..: |||||..|:|.  .|..|||::...:...||.|.:.:
Zfish   278 IIYTGGFQCT-PAKPLPHDLEDFMQSSGDHGVIVMSLGT--FISALPEDVTAEIAAAFARLPQKV 339

  Fly   327 IWKSELLYMPDK----SDNVYVVEQAPQRHILNHPNVRLFITNGGLLSVIEAVDSGVPMLGLPMF 387
            ||:    |...|    .:|..:|:..||:.:|.||..::|:.:||...|.||:..|||::|:|.|
Zfish   340 IWR----YTGKKPSTLGNNTLLVDWMPQKDLLGHPKTKVFVAHGGTNGVQEALYHGVPVVGIPFF 400

  Fly   388 FDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLANNSYYLKAKEISQFFKDRPMSPLDTAV 452
            |||:.|:..:|..|.|:::.:..|.:::|...||.::.|.||.|..:::||...|:|:.|||:|:
Zfish   401 FDQYDNLIRLQARGGAKIVSLAELGENSLHAAIKEVINNPSYRLTMQKLSQLHLDKPVKPLDSAI 465

  Fly   453 WWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSLRFGLVAASLIFLVYTLFLKYRIR 513
            :|.|:.:|::....:|....::|...|:.:|..:.      |:|..||| ::::|  |.:|
Zfish   466 FWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVAVT------LIAVVLIF-IFSIF--YVVR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	120/463 (26%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	130/512 (25%)
ugt5c3	NP_001122186.1	UDPGT	28..530	CDD:278624	132/516 (26%)
ugt5c3	NP_001122186.1	egt	<267..507	CDD:223071	80/252 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585092
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.690