Protein Alignment Ugt303B1 and UGT1A3

DIOPT Version :9

• Sequence 1: NP_651153.1
• Gene: Ugt303B1 / 42775
• FlyBaseID: FBgn0039086
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_061966.1
• Gene: UGT1A3 / 54659
• HGNCID: 12535
• Length: 534
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 130/552 - (23%)
• Similarity: 248/552 - (44%)
• Gaps: 73/552 - (13%)

  Fly     7 WLTLSLCLLLQ-HDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDIEGV 70
            ||...|.|||. ...|::..:| :.|... |.:..|:.::|.|..|||...::||
Human    11 WLATGLLLLLSVQPWAESGKVL-VVPIDG-SHWLSMREVLRELHARGHQAVVLTP---------- 63

  Fly    71 RHIRVAQLNERIKEMLESDQVLDFMINKWTESALTAKAL---------------FNASNDILSDP 120
                  ::|..|||  |:...|......||:.......|               |..|..:|::.
Human    64 ------EVNMHIKE--ENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNM 120

  Fly   121 GV------QRMLHDK-------SESFDLIIMEPSSLDALYGLVEFYN-ATLMGLSSIRINWHTYE 171
            .:      ..:||::       :.|||:::.:|.:|.|.. |.::.: .|:..|.:|..:   .:
Human   121 SLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAV-LAKYLSIPTVFFLRNIPCD---LD 181

  Fly   172 LAGN--PAPSIYEPISPVGFSLETSLFSRVYNWIHIMEEKLVNYLILRP-AQL--HLFQKFFGYS 231
            ..|.  |.||.|.|......|...:...||.|.::.:....:.:....| |.|  .|||:
Human   182 FKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYASLASELFQR----- 241

  Fly   232 AQKMNELRSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLD-KADHGVIY 295
            ...:.::.|..|:.|....:.|...|...||::.:||::.:. .:|..:|.:.::: ..:||::.
Human   242 EVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCAN-RKPLSQEFEAYINASGEHGIVV 305

  Fly   296 FSMGNDILIKFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVVEQAPQRHILNHPNVR 360
            ||:|:  ::..:||.....:......:.::::|:.......:.::|..:|:..||..:|.||..|
Human   306 FSLGS--MVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTR 368

  Fly   361 LFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLA 425
            .|||:.|...|.|::.:||||:.:|:|.||..|.:.::..|....:::..:..:.|...:|.::.
Human   369 AFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVIN 433

  Fly   426 NNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSL 490
            :.||......:|...||||:.|||.||:|.|:.:|::....:|....::...:|:.:| ::.|.|
Human   434 DKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLD-VIGFLL 497

  Fly   491 RFGLVAASLIFLV----YTLFLKYRIRLRRLH 518
            ...|..|.:.|..    |...|..:.|:::.|
Human   498 AVVLTVAFITFKCCAYGYRKCLGKKGRVKKAH 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	112/475 (24%)
		UDPGT	41..511	CDD:278624	118/508 (23%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	121/528 (23%)
		egt	<262..508	CDD:223071	64/249 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150588
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.790