Protein Alignment Ugt303B1 and UGT1A5

DIOPT Version :9

• Sequence 1: NP_651153.1
• Gene: Ugt303B1 / 42775
• FlyBaseID: FBgn0039086
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 130/553 - (23%)
• Similarity: 243/553 - (43%)
• Gaps: 77/553 - (13%)

  Fly     8 LTLSLCLLLQ-HDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDIEGVR 71
            |...|.|||. ...|::..:| :.| ...|.:..|:..:|.|..|||.|.::|
Human    12 LATGLLLLLSVQPWAESGKVL-VVP-TDGSHWLSMREALRDLHARGHQVVVLT------------ 62

  Fly    72 HIRVAQLNERIKEMLESDQVLDFMINKWTESAL-------------TAKALFNASN--------- 114
                .::|..|||  |:...|......||:...             |...|...|.
Human    63 ----LEVNMYIKE--ENFFTLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNMS 121

  Fly   115 --------DILSDPGVQRMLHDKSESFDLIIMEPSSLDALYGLVEFYN-ATLMGLSSIRINWHTY 170
                    ::|.:..:.|.||  :.|||:::.:|..|.|.. |.::.: ..:..|.:|..:   .
Human   122 LIIHRSCVELLHNEALIRHLH--ATSFDVVLTDPFHLCAAV-LAKYLSIPAVFFLRNIPCD---L 180

  Fly   171 ELAGN--PAPSIYEPISPVGFSLETSLFSRVYNWIHIMEEKLVNYLILRP-AQL--HLFQKFFGY 230
            :..|.  |.||.|.|......|...:...||.|.::.:....:.:.:..| |.|  .|||:
Human   181 DFKGTQCPNPSSYIPRLLTTNSDHMTFLQRVKNMLYPLALSYLCHAVSAPYASLASELFQR---- 241

  Fly   231 SAQKMNELRSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLD-KADHGVI 294
             ...:.:|.|..|:.|....:.|...|...||::.:||::.:. .:|..:|.:.::: ..:||::
Human   242 -EVSVVDLVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCAN-GKPLSQEFEAYINASGEHGIV 304

  Fly   295 YFSMGNDILIKFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVVEQAPQRHILNHPNV 359
            .||:|:  ::..:||.....:......:.::::|:.......:.::|..:|:..||..:|.||..
Human   305 VFSLGS--MVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMT 367

  Fly   360 RLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHML 424
            |.|||:.|...|.|::.:||||:.:|:|.||..|.:.::..|....:::..:..:.|...:|.::
Human   368 RAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVI 432

  Fly   425 ANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFS 489
            .:.||......:|...||||:.|||.||:|.|:.:|::....:|....::...:|:.:| ::.|.
Human   433 NDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLD-VIGFL 496

  Fly   490 LRFGLVAASLIFLV----YTLFLKYRIRLRRLH 518
            |...|..|.:.|..    |...|..:.|:::.|
Human   497 LAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAH 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	113/477 (24%)
		UDPGT	41..511	CDD:278624	119/510 (23%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	122/530 (23%)
		egt	<262..508	CDD:223071	64/249 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150586
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.790