Protein Alignment Ugt303B1 and UGT1A7

DIOPT Version :9

• Sequence 1: NP_651153.1
• Gene: Ugt303B1 / 42775
• FlyBaseID: FBgn0039086
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_061950.2
• Gene: UGT1A7 / 54577
• HGNCID: 12539
• Length: 530
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 141/554 - (25%)
• Similarity: 253/554 - (45%)
• Gaps: 81/554 - (14%)

  Fly     8 LTLSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITP-----IGMPNDI 67
            |.|.:||||....|:|..:| :.|... |.:|.||.:|..|..|||.|.::.|     :|
Human    10 LPLYVCLLLTCGFAKAGKLL-VVPMDG-SHWFTMQSVVEKLILRGHEVVVVMPEVSWQLG----- 67

  Fly    68 EGVRHIRVAQLNERIKEMLES----DQVLDFMI---NKWTESALTAKALFNASNDILSD---PGV 122
                    ..||..:|....|    ||..:||:   .:||....:|.:|..:|::.:.|   ...
Human    68 --------RSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLFFSNC 124

  Fly   123 QRMLHD-------KSESFDLIIMEPSSLDALYGLVEFYNATLMGLSSI----RINWHTYELAGN- 175
            :.:.:|       |...||.:.::|  .||. ||:.   |....|.|:    .|..|..|....
Human   125 RSLFNDRKLVEYLKESCFDAVFLDP--FDAC-GLIV---AKYFSLPSVVFARGIFCHYLEEGAQC 183

  Fly   176 PAPSIYEPISPVGFSLETSLFSRVYNWIHIMEEKLVNYLILRPAQLHLFQKFFGYSAQKM----- 235
            |||..|.|...:|||...:...||:|.|..:||             |||..:|..:..::
Human   184 PAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEE-------------HLFCPYFFKNVLEIASEIL 235

  Fly   236 ------NELRSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLD-KADHGV 293
                  .:|.|..|:.|:.:.:.:...:...||:|.:||::..: .:|...|.:.::: ..:||:
Human   236 QTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQ-GKPVPMEFEAYINASGEHGI 299

  Fly   294 IYFSMGNDILIKFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVVEQAPQRHILNHPN 358
            :.||:|:  ::..:||.....:......:.::::|:.......:.::|..:|:..||..:|.||.
Human   300 VVFSLGS--MVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPM 362

  Fly   359 VRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHM 423
            .|.|||:.|...|.|::.:||||:.:|:|.||..|.:.::..|....:::..:..:.|...:|.:
Human   363 TRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAV 427

  Fly   424 LANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAF 488
            :.:.||......:|...||||:.|||.||:|.|:.:|::....:|....::...:|:.:| ::.|
Human   428 INDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLD-VIGF 491

  Fly   489 SLRFGLVAASLIFLV----YTLFLKYRIRLRRLH 518
            .|...|..|.:.|..    |...|..:.|:::.|
Human   492 LLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAH 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	123/479 (26%)
		UDPGT	41..511	CDD:278624	127/512 (25%)
UGT1A7	NP_061950.2	UDPGT	26..521	CDD:278624	131/532 (25%)
		egt	<264..504	CDD:223071	63/243 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150353
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.690