DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B1 and Ugt37B1

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	147/543 - (27%)
Similarity:	249/543 - (45%)	Gaps:	81/543 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LSLCLLLQ----HDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDIEGV 70
            :|.||.||    ...|..|||||:|.....|...:...:.|.||.||||||::|.:..|:..:.:
  Fly     4 ISRCLALQIVVLIAGAHGANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVTILKPPSLHKDI 68

  Fly    71 RHIRVAQ-------LNERIKEMLESDQVLDFMINKWTESALTAKAL---FNASNDILSDPGVQRM 125
            .||.|..       .|..:..|.::|.     .|.:.....:.:.|   |:...|::..|.|:.:
  Fly    69 NHILVPMEEDILQAFNSVVGGMTKTDN-----SNAYVSMFRSVRQLSETFSKMGDVMKQPLVKDL 128

  Fly   126 LHDKSESFDLIIMEPSSLDALYGLVEFYNATLMGLSSIRINWHTYE----------------LAG 174
            .......|||:::.           .|.|...:.|:      |..:                |.|
  Fly   129 YEHPDNKFDLVMVG-----------YFMNCYQLALA------HKLKVPLVVALSNPPSFLGYLLG 176

  Fly   175 NPAPSIYEP---IS-----PVGFSLETSLFSRVYNWIHIMEEKLVNYLI-LRPAQLHLFQKFFG- 229
            ||....|.|   :|     |:||.      .||.|.:..|.::|..::| ||.|:  ::::.:|
  Fly   177 NPWEVSYVPGMSVSIKGGKPLGFG------HRVLNLLGSMAQRLFMFIIELRNAR--IYREIYGD 233

  Fly   230 -YSAQKMNELRSRFSLMLINSH-YSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDKADHG 292
             .:.....:|....||:...|| .|.|.:|.|.|.:||:||:.:.|.||...:.:::||.:|.:|
  Fly   234 DPTLPSYEDLHKNISLIFFASHGISEGPIRPNVPAVIEIGGIQVKEQPERLPQNMEQFLSEAPNG 298

  Fly   293 VIYFSMGNDILIKFLPENIQELLLQTFATLNESIIWK-SELLYMPDKSDNVYVVEQAPQRHILNH 356
            .|..|:|:::....|..:..:.:....:.|.:.:||| .:|..:|.:|:|:...:..||..:|.|
  Fly   299 AILLSLGSNLKEDHLKSSTVQKMFNVLSKLQQKVIWKWDDLDNIPGESENILYSKWVPQVDVLAH 363

  Fly   357 PNVRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIK 421
            ||:.||||:.|...:.||...|.|||.||:|.||..|...:.:.|......|.:|.:|:..:.|:
  Fly   364 PNITLFITHAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIR 428

  Fly   422 HMLANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLI--EYYRIDS 484
            .:|.|..|....|..|..::|||:||.:|.::|.||.:|......:     :.|::  .|...::
  Fly   429 EVLDNPKYATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHI-----QSPVVHMSYIAANN 488

  Fly   485 ILAFSLRFGLVAASLIFLVYTLF 507
            :..:::..|.:.| |.|:...||
  Fly   489 LDVYAVILGTIVA-LCFITKLLF 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	134/479 (28%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	134/508 (26%)
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	142/535 (27%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	135/504 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445804
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950