DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B1 and Ugt37D1

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	155/545 - (28%)
Similarity:	262/545 - (48%)	Gaps:	76/545 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RYCWLTLSL------CLLLQ--HDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITP 60
            |..|:..||      .|.||  ....:.|||||:|.....|.|.|...:::|||.:|||||:::.
  Fly     5 RSTWIGCSLGGLLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSS 69

  Fly    61 IGMPNDIEGVRHIRVAQ-------LNERIKEML-ESDQVLDFMINKWTESALTAKALFNASNDIL 117
            :......:.:.||.|..       ||:.:..|: |...:.:.|.:.::..||    |.:...|:|
  Fly    70 VPPKVTHKSINHIVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSIFSSLAL----LIDKQVDVL 130

  Fly   118 SDPGVQRMLHDKSESFDLIIMEPSSLDALYGLVEFYNATLMGLSS-----IRINWH------TYE 171
            .||..|.:..:|...||::.:         |.  |:|...:.|.:     :.|:|.      ..|
  Fly   131 EDPRFQELYLNKGNKFDVVFV---------GF--FFNTYQVALGARFNCPVIISWSGPPMMMVNE 184

  Fly   172 LAGNP----APSIY---EPISPVGFSLETSLFSRVYNWIHIMEEKLVNYLILRPAQLHLFQKFFG 229
            :.|||    .|.::   .|..|:.|.      .|:.|:...:....:|..:     .|.:.||:.
  Fly   185 VLGNPELSSVPQMHISAPPGQPMNFQ------QRMQNFASTLGFNALNIFL-----NHKYNKFYD 238

  Fly   230 --YSAQK----MNELRSRFSLMLINSH-YSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLD 287
              :|..|    ..:.:...||...|.| .|.|.:|.|.|.:||:||:.:...|:|..|::|:||:
  Fly   239 RLWSKDKSMPTFAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDPLPEDIQEFLE 303

  Fly   288 KADHGVIYFSMGNDILIKFLPENIQELLLQTFATLNESIIWK-SELLYMPDKSDNVYVVEQAPQR 351
            |..||.|.||:|:::..:.:...:.:.:.:..::|.:.:||| .:....|.||.|:...:..||.
  Fly   304 KGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSANILYKKWLPQD 368

  Fly   352 HILNHPNVRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTL 416
            .||.||.::||||:.|...|.||...|||||.||:|.||.||...:..||....:.:.:|:.|..
  Fly   369 DILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQLPLATLDVDEF 433

  Fly   417 TETIKHMLANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYR 481
            ...||.::.|..|....|..||.::|||:||.::.|:||||.:|:.....|     :.||:   .
  Fly   434 KAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHM-----QSPLV---H 490

  Fly   482 IDSILAFSLRFGLVAASLIFLVYTL 506
            ::.|.:.:|...::||.::::|:.:
  Fly   491 MNFIASNNLDIYIIAALVLYIVFII 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	140/474 (30%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	139/500 (28%)
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	147/520 (28%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	142/505 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445706
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950