DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B1 and RGD1559459

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_003751392.1	Gene:	RGD1559459 / 501907	RGDID:	1559459	Length:	530	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	127/553 - (22%)
Similarity:	238/553 - (43%)	Gaps:	104/553 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LSLCLLLQH-----DRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPI-------- 61
            ::..|||.|     .......:| ::|. ..|.:..::.::..|..:||.|.::.|.
  Rat     5 MTAALLLLHLTIFFGSGSGGKVL-VWPV-EFSHWLNLKIILSELVKKGHEVVVLKPSVSFSYEVD 67

  Fly    62 --------GMPN--DIEGVRHIRVAQLNERIKEMLESDQVLDFMINKWTESALTAKALFNASND- 115
                    ..|:  .|..|..|.:..:||.|.|:.:.        :.|....:..| ||..::|
  Rat    68 KTSAIEFESFPSSYSIADVEVIFMDCVNESIYELPKQ--------SFWGYFLMLQK-LFERTSDY 123

  Fly   116 ---ILSDPGVQRMLHDK--SESFDLIIMEPSS-----------LDALYGLVEFYNATLMGLSSIR 164
               :..|....:.|..|  :..||:|:.:|.:           :..:|.| .|:..:
  Rat   124 SERLCRDAAFNKELMTKLQNSGFDVILADPFTPCGDLLAEILKIPLVYSL-RFFPGS-------- 179

  Fly   165 INWHTYE--LAGNPAPSIYEPISPVGFSLETSLFSRVYN---------WIHIMEEKLVNYL---- 214
                |||  ..|.|.|..|.||:....|...:...||.:         |..:.:||..|.|
  Rat   180 ----TYEKYSGGLPMPPSYVPIAMSELSDRMTFVERVKHMIYVLCFDFWFQVFDEKKWNELYTEV 240

  Fly   215 ILRPAQLHLFQKFFGYSAQKMNELRSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSD 279
            :.||..|              :|..::..:.||.:::.:.......||...||||| ..|.:|..
  Rat   241 LGRPTTL--------------SETMAKADIWLIRTYWDLEFPHPVLPNFDFVGGLH-CRPAKPLP 290

  Fly   280 EELQKFLDKA-DHGVIYFSMGNDILIKFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVY 343
            :|::.|:..: :|||:.||:|:  ::..|.|....::....|.:.:.::|:.|.........|..
  Rat   291 KEIEDFVQSSGEHGVVVFSLGS--MVGSLTEERANVIAAGLAQIPQKVLWRFEGKKPETLGSNTR 353

  Fly   344 VVEQAPQRHILNHPNVRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDI 408
            :.:..||..:|.||..|.|||:||...:.||:..|:|::|:|:|.||..|:..::..|.|..:|.
  Rat   354 LYKWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPVVGIPLFGDQKDNIVHLKTKGAAVRLDF 418

  Fly   409 NSLNKDTLTETIKHMLANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEE 473
            .:::...|...::.:..:.||...|..:|:...|:|:.|||.||:|.|:.:|::....:|:...:
  Rat   419 LTMSSTDLLTALRTVTNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAGHD 483

  Fly   474 IPLIEYYRIDSILAFSLRFGLVAASLIFLVYTL 506
            :..::|:.:|.|       |.:.|.::.:::.|
  Rat   484 LSWVQYHSLDVI-------GFLLACVVTVMFIL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	116/491 (24%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	120/517 (23%)
RGD1559459	XP_003751392.1	UDPGT	24..527	CDD:278624	123/534 (23%)
RGD1559459	XP_003751392.1	egt	<270..508	CDD:223071	68/247 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344081
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.640