DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B1 and Ugt37A2

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	148/547 - (27%)
Similarity:	245/547 - (44%)	Gaps:	68/547 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YCWLTLSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDIEG 69
            |..|..::|:|   .....|||||:|.....|...:.....:.||.||||||:||.:....:.:.
  Fly     8 YLLLATAICVL---GGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPVVNHKN 69

  Fly    70 VRHIRVAQLNERIKEMLESDQVLDFM--INKWTESALTAKAL---------FNASNDILSDPGVQ 123
            :..|.|....|      ||.|:.|.:  ::|...|.:....|         |:.....|.|..|:
  Fly    70 ITVIMVPLTKE------ESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKDDRVR 128

  Fly   124 RMLHDKSESFDLII----MEPSSLDALYGLVEFYNATLMGLSSIRINWHTYELAGNP-----APS 179
            .:..::...|||::    |....|    |..:...|.::.::::..|.....|.|||     .||
  Fly   129 DLYLNRDNKFDLVLSGYFMNVYQL----GFAKKVKAPVIVVATMPPNQLLNPLIGNPLEIAYVPS 189

  Fly   180 IYEPISP----------VGFSLETSLFSRVYNWIHIMEEKLVNYLILRPAQLHLFQKFFG--YSA 232
            |.:.:..          .|:|  :|.|..:::::.....|            .|:::.||  .:.
  Fly   190 ISDSVEKGKGMSFRQRLAGYS--SSFFFGIFDFVTQRRSK------------RLYKELFGDDPNM 240

  Fly   233 QKMNELRSRFSLMLINSHY-SMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDKADHGVIYF 296
            .:.:||....||:...||. |.|.:|.|.|..||:||:.:.:.|:|..:.:.:||..|..|.|..
  Fly   241 PEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNATDGAILL 305

  Fly   297 SMGNDILIKFLPENIQELLLQTFATLNESIIWK-SELLYMPDKSDNVYVVEQAPQRHILNHPNVR 360
            |:|:::....:..:....:....:.|.:.:||| .:|...|.||||::..:..||..||.|||::
  Fly   306 SLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNIK 370

  Fly   361 LFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLA 425
            |||.:.|...:.||...|.|||.||:|.||.||...:...|......:.||.:....|.|..:|:
  Fly   371 LFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILS 435

  Fly   426 NNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSL 490
            |..|:.|....|..::|||||..::.::||||.:|:.....::..|..:..|....||.
  Fly   436 NPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDI------ 494

  Fly   491 RFGLVAASLIFLVYTLFLKYRIRLRRL 517
             :.|:|..|:.||..|.|..:...|::
  Fly   495 -YALIAVVLVILVLLLKLLLQFIYRKI 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	132/474 (28%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	136/503 (27%)
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	138/508 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445720
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950