DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B1 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_958826.1	Gene:	Ugt1a2 / 396527	RGDID:	1549741	Length:	533	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	128/536 - (23%)
Similarity:	239/536 - (44%)	Gaps:	82/536 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTLSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDIEGVRH 72
            |.|.||.|   ..|:...:| :||... |.:..|:.:||.|..|||...::.|       |...|
  Rat    15 LLLLLCAL---PWAEGGKVL-VFPMEG-SHWLSMRDVVRELHARGHQAVVLAP-------EVTVH 67

  Fly    73 IRVAQL------------NERIKEMLESDQ---VLDFMINKWTESALTAKALFNASNDILSDPGV 122
            ::....            .|..:|:|.:.:   .....:..:.|:..:.|..|    |:.:: ..
  Rat    68 MKGEDFFTLQTYAFPYTKEEYQREILGNAKKGFEPQHFVKTFFETMASIKKFF----DLYAN-SC 127

  Fly   123 QRMLHDK-------SESFDLIIMEP----SSLDALY---GLVEFYNATLMGLSSIRINWHTYELA 173
            ..:||:|       |.|||:::.:|    .:|.|.|   ..|.|..:...|:.        ||..
  Rat   128 AALLHNKTLIQQLNSSSFDVVLTDPVFPCGALLAKYLQIPAVFFLRSVPCGID--------YEAT 184

  Fly   174 GNPAPSIYEPISPVGFSLETSLFSRVYNWIHIMEEKLVNYLILRPAQLHLFQKFFGYSAQKMNEL 238
            ..|.||.|.|......|...:...||.|.::.:..|.:.:|.:.|           |.:.....|
  Rat   185 QCPKPSSYIPNLLTMLSDHMTFLQRVKNMLYPLTLKYICHLSITP-----------YESLASELL 238

  Fly   239 RSRFSLMLINSHYSMGKVRAN---------APNIIEVGGLHLSEPPEPSDEELQKFLD-KADHGV 293
            :...||:.:.||.|:...|.:         .||::.:||:: ....:|..:|.:.::: ..:||:
  Rat   239 QREMSLVEVLSHASVWLFRGDFVFDYPRPIMPNMVFIGGIN-CVIKKPLSQEFEAYVNASGEHGI 302

  Fly   294 IYFSMGNDILIKFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVVEQAPQRHILNHPN 358
            :.||:|:  ::..:||.....:.:....:.::::|:.......:.:.|..:|:..||..:|.||.
  Rat   303 VVFSLGS--MVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPK 365

  Fly   359 VRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHM 423
            .|.|||:.|...:.|.:.:||||:.:|:|.||..|.:.::..|....:::..:..|.|...:|.:
  Rat   366 ARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTV 430

  Fly   424 LANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAF 488
            :.|.||......:|...||||:.|||.||:|.||.:|::....:|....::...:|:.:| ::.|
  Rat   431 INNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLD-VIGF 494

  Fly   489 SLRFGLVAASLIFLVY 504
            .|   .:..:::|:||
  Rat   495 LL---AIVLTVVFIVY 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	115/479 (24%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	118/503 (23%)
Ugt1a2	NP_958826.1	UDPGT	28..524	CDD:278624	122/520 (23%)
Ugt1a2	NP_958826.1	egt	<261..507	CDD:223071	63/252 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810