DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B1 and Ugt1a9

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_964006.2	Gene:	Ugt1a9 / 394434	MGIID:	3576092	Length:	528	Species:	Mus musculus

Alignment Length:	524	Identity:	127/524 - (24%)
Similarity:	243/524 - (46%)	Gaps:	64/524 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITP-----IGMPNDIEGVR 71
            |||||....|||..:| :.|... |.:|.||.:|..|..|||.|.::.|     :|...:..
Mouse    12 LCLLLASGLAQAGRLL-VVPMDG-SHWFTMQMVVEKLIHRGHEVVVVIPEVSWQLGKSLNCT--- 71

  Fly    72 HIRVAQLNERIKEMLESDQVLDFMINKW------TESALTAKA------LFNASNDILSDPGVQR 124
             ::...::..::::....:.|.:  .:|      ..|.||..|      .|:....:.:|..:..
Mouse    72 -VKTYSISHTLEDLDREFKYLSY--TQWKTPEHSIRSFLTGSARGFFELTFSHCRSLFNDKKLVE 133

  Fly   125 MLHDKSESFDLIIMEPSSLDALYGLVEFYNATLMGLSSIRINWHTYELAGNPAPSI--YEPISPV 187
            .|  |...||.:.::|..   :.||:.....:|..:...|..:..|...|...||:  |.|
Mouse   134 YL--KQRFFDAVFLDPFD---VCGLIVAKYFSLPSVIFARGVFCDYLEEGAQCPSLPSYVP---- 189

  Fly   188 GFSLETSLFSRVYNWIHIMEEKLVNYLILRPAQLHLFQKFFGYSAQK-----------MNELRSR 241
                  .|||: |......:|::.|:||.  .:.|.|..:|..:|.:           |.:|.|.
Mouse   190 ------RLFSK-YTDTMTFKERVWNHLIY--IEEHAFCSYFLRTAVEVASEILQTPVTMTDLFSP 245

  Fly   242 FSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLD-KADHGVIYFSMGNDILIK 305
            .|:.|:.:.:.:...|...||::.:||::..:....| :|.:.::: ..:||::.||:|:  ::.
Mouse   246 VSIWLLRTDFVLEFPRPVMPNMVFIGGINCLQKKSLS-KEFEAYVNASGEHGIVVFSLGS--MVS 307

  Fly   306 FLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVVEQAPQRHILNHPNVRLFITNGGLLS 370
            .:||.....:.:....:.::::|:.......:.:.|..:|:..||..:|.||..|.|||:.|...
Mouse   308 EIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHG 372

  Fly   371 VIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLANNSYYLKAKE 435
            :.|.:.:||||:.:|:|.||..|.:.::..|....:::..:..|.|...:|.::.|.||......
Mouse   373 IYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMR 437

  Fly   436 ISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSLRFGLVAASLI 500
            :|...||||:.|||.||:|.||.:|::....:|....::...:|:.:| ::.|.|   .:..:::
Mouse   438 LSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLD-VIGFLL---AIVLTVV 498

  Fly   501 FLVY 504
            |:|:
Mouse   499 FIVF 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	115/471 (24%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	115/495 (23%)
Ugt1a9	NP_964006.2	egt	9..500	CDD:223071	125/520 (24%)
Ugt1a9	NP_964006.2	UDPGT	24..519	CDD:278624	119/512 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840343
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.640