DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B1 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_964004.1	Gene:	Ugt1a7c / 394432	MGIID:	3032636	Length:	531	Species:	Mus musculus

Alignment Length:	528	Identity:	132/528 - (25%)
Similarity:	239/528 - (45%)	Gaps:	63/528 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTLSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLIT---------PIGM 63
            |.|.:||||....|||..:| :.|... |.:|.||.:|..|..:||.|.::.         |:..
Mouse    10 LPLCVCLLLASGLAQAGRLL-VVPMDG-SHWFTMQTVVEKLLHKGHEVVVVVPEVSWQLTKPLNF 72

  Fly    64 PNDIEGVRHIRVAQLNERIKEMLESD----------QVLDFMINKWTESALTAKALFNASNDILS 118
            ......|.|.: ..||...|..:::.          .:||.....:.|      .||:....:.:
Mouse    73 VVKTYAVSHTQ-EDLNREFKIFIDAQWKSQQEGGILPLLDSPAKGFFE------LLFSHCRSLFN 130

  Fly   119 DPGVQRMLHDKSESFDLIIMEPSSLDALYGLVEFYNATLMGLSSIRINWHTYELAGN-PAPSIYE 182
            |..:...|  |..|||.:.::|..:..|  .|..|.:....:.|..|..|..|.|.. |:|..|.
Mouse   131 DKKLVEYL--KQTSFDAVFLDPFDVCGL--TVAKYFSLPSVVFSRGIFCHYLEDAAQCPSPPSYI 191

  Fly   183 PISPVGFSLETSLFSRVYNWIHIMEEKLVNYLILRPAQLHLFQKFFGYSAQ----------KMNE 237
            |...:.|:...:...|..|.:..|.|:         |..|   |||..:|.          .|.:
Mouse   192 PRMLLKFTDTMTFKERTRNLLAYMGER---------AFCH---KFFKSAADIASEVLQTPVTMTD 244

  Fly   238 LRSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLD-KADHGVIYFSMGND 301
            |.|..|:.|:.:.:.:...|...||:|.:||::..: .:|..:|.:.::: ..:||::.||:|:
Mouse   245 LFSPVSIWLLRTDFVLEFPRPVMPNVIYIGGINCHQ-GKPLSKEFEAYVNASGEHGIVVFSLGS- 307

  Fly   302 ILIKFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVVEQAPQRHILNHPNVRLFITNG 366
             ::..:||.....:.:....:.::::|:.......:.:.|..:|:..||..:|.||..|.|||:.
Mouse   308 -MVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHS 371

  Fly   367 GLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLANNSYYL 431
            |...:.|.:.:||||:.:|:|.||..|.:.::..|....:::..:..|.|...:|.::.|.||..
Mouse   372 GSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKE 436

  Fly   432 KAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSLRFGLVA 496
            ....:|...||||:.|||.||:|.||.:|::....:|....::...:|:.:| ::.|.|   .:.
Mouse   437 NIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLD-VIGFLL---AIV 497

  Fly   497 ASLIFLVY 504
            .:::|:|:
Mouse   498 LTVVFIVF 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	119/471 (25%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	119/495 (24%)
Ugt1a7c	NP_964004.1	UDPGT	26..522	CDD:278624	123/512 (24%)
Ugt1a7c	NP_964004.1	egt	<225..503	CDD:223071	71/284 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840679
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.640