DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B1 and Ugt49B1

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	153/529 - (28%)
Similarity:	256/529 - (48%)	Gaps:	58/529 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDIEG--VRH 72
            |||..|.|.:....:.||..|.:...|.|.:...::|.|..:||.||.|||..:..:..|  .:.
  Fly    12 LSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGSNYKE 76

  Fly    73 IRVAQLN--ERIKEMLESDQVLDF----------MINKWTESALTAKALFNASNDILSDPGVQRM 125
            |.:.|.:  ..||||...:.||:.          |:|...         .:.::..|..|.:|.:
  Fly    77 IVIPQYDFWPEIKEMTNKNTVLEMTDLPTFAFLRMVNVMG---------IHTTDFALEQPEIQAV 132

  Fly   126 LHDKSE--SFDLIIMEPSSLDALYGLVEFYN--ATLMG----LSSIRINW-----HTYELAGNPA 177
            :::|::  .:||::.|           :|:|  |.::|    :.:|.|:.     |..:|.|..:
  Fly   133 INEKNKIGKYDLLLAE-----------QFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVS 186

  Fly   178 PSIYEPISPVGFSLETSLFSRVYNWIHIMEEKLVNYLILRPAQLHLFQKFFGYSAQK---MNELR 239
            |..|.|.:.:.::...:|:.|:.|......|.||......|.|..:.:|.|.....:   :.||.
  Fly   187 PWSYVPHAYMPYTDRMTLWERIGNVAMSAAEDLVREFSYYPGQDAVLKKHFSKLLDRVPTIKELE 251

  Fly   240 SRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDKADHGVIYFSMGNDILI 304
            ...|.:|:||:..:...|..|.|:|.|||||: :||:...|.||||||.|.||.||||:|:.:..
  Fly   252 RNISAILLNSYMPLASSRPMAYNMIPVGGLHI-QPPKALPEHLQKFLDGATHGAIYFSLGSQVRS 315

  Fly   305 KFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVVEQAPQRHILNHPNVRLFITNGGLL 369
            ..||....::.|:.|.:|.:.::||.|...:|:...||.|....||..||.||||::||.:|||.
  Fly   316 ADLPPEKLKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLF 380

  Fly   370 SVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLANNSYYLKAK 434
            ...|||.:|||:||:|::.||..|:...:.:..|..:|...:..:.|...:..::.|..|....|
  Fly   381 GTQEAVYNGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIK 445

  Fly   435 EISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSLRFGLVAASL 499
            :.|:.|:|||:..:|||::|..|.:.:|....:......:|..::|.:|.:       ||..|.:
  Fly   446 KASRIFRDRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIV-------GLGLAVI 503

  Fly   500 IFLVYTLFL 508
            :..:..|.|
  Fly   504 LLPIVVLIL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	139/470 (30%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	143/498 (29%)
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	153/529 (29%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	145/503 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454715
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	9.790