DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B1 and Ugt2b37

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001007265.4	Gene:	Ugt2b37 / 29623	RGDID:	3937	Length:	530	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	129/561 - (22%)
Similarity:	240/561 - (42%)	Gaps:	97/561 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTLSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGM----PNDIE 68
            |.:|.||    ..|:...:| ::| ...|.:..::.::..|..|||.||::.|...    |....
  Rat    12 LQISFCL----RSAKCGKVL-VWP-MEFSHWMNIKTILDELVQRGHEVTVLKPSAYYVLDPKKSP 70

  Fly    69 GVRHIRVAQLNERIKEMLESDQVLDF---MINKWT-----ESALTAKALFNASNDILSD------ 119
            .::.       |.....:..|::..:   :::.||     ::.|:...|.....|..||
  Rat    71 DLKF-------ETFPTSVSKDELEKYFIKLVDAWTYELQRDTCLSFSPLLQNMMDEFSDYYLSVC 128

  Fly   120 ----PGVQRMLHDKSESFDLIIMEPSSLDALYGLVEFYNATLMGLSSIRINWHTYELAGNPA--- 177
                ...|.|...:...||:::.:|  :.|...|:    |.::.:..:      |.|..:|.
  Rat   129 KDAVSNKQLMAKLQESKFDVLLSDP--VAACGELI----AEVLHIPFL------YSLRASPGHKI 181

  Fly   178 ---------PSIYEPISPVGFSLETSLFSRVYN---------WIHIMEEK----LVNYLILRPAQ 220
                     |..|.|:...|...:.:...||.|         |.|:...|    ....::.||..
  Rat   182 EKSSGRFILPPSYVPVILSGLGGQMTFIDRVKNMICMLYFDFWFHMFNAKNWDPFYTEILGRPTT 246

  Fly   221 LHLFQKFFGYSAQKMNELRSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKF 285
            |              .|...:..:.||.|::.:.......||:..:|||. .:|.:|..::::.|
  Rat   247 L--------------AETMGKAEMWLIRSYWDLEFPHPTLPNVDYIGGLQ-CKPAKPLPKDIEDF 296

  Fly   286 LDKA-DHGVIYFSMGNDILIKFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVVEQAP 349
            :..: :|||:.||:|:  ::..:.|.....:....|.:.:.::||.:.........|..|.:..|
  Rat   297 VQSSGEHGVVVFSLGS--MVSSMTEEKANAVAWALAQIPQKVLWKFDGKIPATLGPNTRVYKWLP 359

  Fly   350 QRHILNHPNVRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKD 414
            |..:|.||..:.|:|:||...|.||:..|:||:|:|||.:|..|:..:...|.|..::|.:::|.
  Rat   360 QNDLLGHPKTKAFVTHGGANGVYEAIYHGIPMIGIPMFGEQHDNIAHMVAKGAAVTLNIRTMSKS 424

  Fly   415 TLTETIKHMLANNSYYLK-AKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIE 478
            .|...:|.:: ||.:|.| |..:|....|:||.|||.|::|.||.:|::....:|.....:|..:
  Rat   425 DLFNALKEVI-NNPFYKKNAMWLSTIHHDQPMKPLDKAIFWIEYVMRHKRAKHLRPLGHNLPWYQ 488

  Fly   479 YYRIDSILAFSLRFGLVAASL----IFLVYTLFLKYRIRLR 515
            |:.:| ::.|.|....|.|:|    ...:|..|.|.:.:::
  Rat   489 YHSLD-VIGFLLACLAVIAALAVKCFLFIYRFFAKKQKKMK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	113/489 (23%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	121/522 (23%)
Ugt2b37	NP_001007265.4	UDPGT	24..527	CDD:278624	124/542 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.710