DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B1 and Ugt2b17

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_775417.1	Gene:	Ugt2b17 / 286954	RGDID:	708541	Length:	529	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	134/554 - (24%)
Similarity:	245/554 - (44%)	Gaps:	102/554 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SLCLLLQ---HDRAQAANILGIFP--YRHISPFFVMQPLVRTLATRGHNVT--------LITPIG 62
            |:.||:|   :.|..|...:.::|  |.|   :..::.::..||.|||.||        ||.|
  Rat     7 SVFLLIQLICYFRPGACGKVLVWPTEYSH---WINIKIILNELAQRGHEVTVLVSSASILIEP-- 66

  Fly    63 MPNDIEGVRHIRVAQLNERIKEMLESDQVLDFMINKW---------TESALT----AKALFNASN 114
                      .:.:.:|..|..:..|...|::...||         |.|..|    .:.:||..:
  Rat    67 ----------TKESSINFEIYSVPLSKSDLEYSFAKWIDEWTRDFETLSIWTYYSKMQKVFNEYS 121

  Fly   115 DILSDPGVQRMLHDKS-------ESFDLIIMEPSSLDALYG-----LVEFYNATLMGLSSIRI-- 165
            |::.:. .:.::.:||       ..||:|:     .||: |     |.|.....|  :.|:|.
  Rat   122 DVVENL-CKALIWNKSLMKKLQGSQFDVIL-----ADAV-GPCGELLAELLKTPL--VYSLRFCP 177

  Fly   166 NWHTYELAGN-PAPSIYEPISPVGFSLETSLFSRVYN---------WIHIMEEK----LVNYLIL 216
            .:...:.:|. |.|..|.|:.....|...:...||.|         |....:||    ..:.::.
  Rat   178 GYRCEKFSGGLPLPPSYVPVVLSELSDRMTFVERVKNMLQMLYFDFWFQPFKEKSWSQFYSDVLG 242

  Fly   217 RPAQLHLFQKFFGYSAQKMNELRSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEE 281
            ||..|              .|:..:..:.||.:.:.:.......||...||||| .:|.:|...|
  Rat   243 RPTTL--------------TEMMGKADIWLIRTFWDLEFPHPFLPNFDFVGGLH-CKPAKPLPRE 292

  Fly   282 LQKFLDKA-DHGVIYFSMGNDILIKFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVV 345
            :::|:..: :|||:.||:|:  ::|.|.|....::....|.:.:.::|:.:.........|..:.
  Rat   293 MEEFVQSSGEHGVVVFSLGS--MVKNLTEEKANVVASALAQIPQKVVWRFDGKKPDTLGSNTRLY 355

  Fly   346 EQAPQRHILNHPNVRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINS 410
            :..||..:|.||..:.|:.:||...:.||:..|:|::|:|:|.||..|:..:...|.|..:|.:.
  Rat   356 KWIPQNDLLGHPKTKAFVAHGGTNGIYEAIYHGIPIVGIPLFADQPDNINHMVAKGAAVRVDFSI 420

  Fly   411 LNKDTLTETIKHMLANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIP 475
            |:...|...:|.::.:.||...|..:|:...|:|:.|||.||:|.||.:|::....:|..|.::.
  Rat   421 LSTTGLLTALKIVMNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEYVMRHKGAKHLRSTLHDLS 485

  Fly   476 LIEYYRIDSILAFSLRFGLVAASLIFLV--YTLF 507
            ..:|:.:| ::.|.|   |....::|::  :.||
  Rat   486 WFQYHSLD-VIGFLL---LCVVGVVFIITKFCLF 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	119/492 (24%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	125/519 (24%)
Ugt2b17	NP_775417.1	UDPGT	24..527	CDD:278624	128/537 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.710