DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B1 and Ugt2b15

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_695226.3	Gene:	Ugt2b15 / 266685	RGDID:	628623	Length:	530	Species:	Rattus norvegicus

Alignment Length:	566	Identity:	132/566 - (23%)
Similarity:	241/566 - (42%)	Gaps:	99/566 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WLTLSLCLLLQ----HDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGM---- 63
            |  :|..||||    ........:| ::| ...|.:..::.::..|..|||.||::.|...
  Rat     5 W--ISALLLLQISCCFQSGNCGKVL-VWP-MEFSHWMNIKTILDELVQRGHEVTVLKPSAYYVLD 65

  Fly    64 PNDIEGVRHIRVAQLNERIKEMLESDQVLDF---MINKWT-----ESALTAKALFNASNDILSD- 119
            |.....::.       |.....:..|::.::   :::.||     ::.|:...|.....|..||
  Rat    66 PKKSPDLKF-------ETFPTSVSKDELENYFIKLVDVWTYELQRDTCLSYSPLLQNMIDGFSDY 123

  Fly   120 ---------PGVQRMLHDKSESFDLIIMEPSSLDALYGLVEFYNATLMGLSSIRINWHTYELAGN 175
                     ...|.|...:...||:::.:|  :.|...|:    |.::.:..:      |.|..:
  Rat   124 YLSLCKDTVSNKQLMAKLQESKFDVLLSDP--VAACGELI----AEVLHIPFL------YSLRFS 176

  Fly   176 PA------------PSIYEPISPVGFSLETSLFSRVYN---------WIHIMEEK----LVNYLI 215
            |.            |..|.|:...|.....:...||.|         |.|:...|    ..:.::
  Rat   177 PGYKIEKSSGRFILPPSYVPVILSGMGGPMTFIDRVKNMICTLYFDFWFHMFNAKKWDPFYSEIL 241

  Fly   216 LRPAQLHLFQKFFGYSAQKMNELRSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDE 280
            .||..|              .|...:..:.||.|::.:.......||:..:|||. ..||:|..:
  Rat   242 GRPTTL--------------AETMGKAEMWLIRSYWDLEFPHPTLPNVDYIGGLQ-CRPPKPLPK 291

  Fly   281 ELQKFLDKA-DHGVIYFSMGNDILIKFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYV 344
            :::.|:..: :|||:.||:|:  ::..:.|.....:....|.:.:.::||.:.........|..|
  Rat   292 DMEDFVQSSGEHGVVVFSLGS--MVSSMTEEKANAIAWALAQIPQKVLWKFDGKTPATLGPNTRV 354

  Fly   345 VEQAPQRHILNHPNVRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDIN 409
            .:..||..:|.||..:.|:|:||...|.||:..|:||:|:|||.:|..|:..:...|.|..::|.
  Rat   355 YKWLPQNDLLGHPKTKAFVTHGGANGVYEAIYHGIPMVGIPMFGEQHDNIAHMVAKGAAVTLNIR 419

  Fly   410 SLNKDTLTETIKHMLANNSYYLK-AKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEE 473
            :::|..|...:|.:: ||.:|.| |..:|....|:||.|||.||:|.|:.:|::....:|.....
  Rat   420 TMSKSDLFNALKEII-NNPFYKKNAVWLSTIHHDQPMKPLDKAVFWIEFVMRHKGAKHLRPLGHN 483

  Fly   474 IPLIEYYRIDSILAFSLRFGLVAASL----IFLVYTLFLKYRIRLR 515
            :|..:|:.:| ::.|.|....|.|.|    ...:|.||:|...:::
  Rat   484 LPWYQYHSLD-VIGFLLTCSAVIAVLTVKSFLFIYRLFVKKEKKMK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	113/489 (23%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	123/522 (24%)
Ugt2b15	NP_695226.3	UDPGT	24..527	CDD:278624	126/542 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344083
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.640