DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B1 and Ugt2b

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_113721.5	Gene:	Ugt2b / 24862	RGDID:	3936	Length:	530	Species:	Rattus norvegicus

Alignment Length:	565	Identity:	125/565 - (22%)
Similarity:	244/565 - (43%)	Gaps:	105/565 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTLSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGM----PNDIE 68
            |.:|.|....|    ...:| ::| ...|.:..::.::..|..|||.||::.|...    |....
  Rat    12 LQISYCFKSGH----CGKVL-VWP-MDFSHWMNIKIILDELVQRGHEVTVLKPSAYFFLDPKKSS 70

  Fly    69 GVRHIRVAQLNERIKEMLESDQVLDF---MINKWT-----ESALTAKAL------------FNAS 113
            .::.       |.....:..|::.:.   :::.||     ::.|:...:            .:..
  Rat    71 DLKF-------EIFSTSISKDELQNHFIKLLDVWTYELPRDTCLSYSPILQNLVYEFSYFYLSIC 128

  Fly   114 NDILSDPGVQRMLHDKSESFDLIIMEP--SSLDALYGLVEFYNATLMGLSSIRINWHTYELAGNP 176
            .|.:|:.  |.|...:...||::..:|  |..|.:        |.|:.:..:      |.|:.:|
  Rat   129 KDAVSNK--QLMTKLQESKFDVLFADPVASCGDLI--------AELLHIPFL------YSLSFSP 177

  Fly   177 A------------PSIYEPISPVGFSLETSLFSRVYN---------WIHIMEEK----LVNYLIL 216
            .            |..|.|:...|.:.:.:...||.|         |..|:..|    ..:.::.
  Rat   178 GHKLEKSIGKFILPPSYVPVILSGLAGKMTFIDRVKNMICMLYFDFWFEILRHKEWDTFYSEILG 242

  Fly   217 RPAQLHLFQKFFGYSAQKMNELRSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEE 281
            ||.              .::|..|:..:.||.|::.:.......||:..:|||| .:|.:|..::
  Rat   243 RPT--------------TVDETMSKVEIWLIRSYWDLKFPHPTLPNVDYIGGLH-CKPAKPLPKD 292

  Fly   282 LQKFLDKA-DHGVIYFSMGNDILIKFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVV 345
            :::|:..: :|||:.||:|:  ::..:.|.....:....|.:.:.::||.:.........|..|.
  Rat   293 MEEFVQSSGEHGVVVFSLGS--MVSNMTEEKANAIAWALAQIPQKVLWKFDGKTPATLGPNTRVY 355

  Fly   346 EQAPQRHILNHPNVRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINS 410
            :..||..||.||..:.|:|:||...:.||:..|:||:|:|:|.||..|:..:...|.|..::|.:
  Rat   356 KWLPQNDILGHPKTKAFVTHGGANGLYEAIYHGIPMIGIPLFGDQPDNIAHMVAKGAAVSLNIRT 420

  Fly   411 LNKDTLTETIKHMLANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIP 475
            ::|......::.::.|..|......:|....|:||.|||.||:|.|:.:|::....:|.....:|
  Rat   421 MSKLDFLSALEEVIDNPFYKKNVMLLSTIHHDQPMKPLDRAVFWIEFIMRHKGAKHLRPLGHNLP 485

  Fly   476 LIEYYRIDSILAFSLR-FGLVAA----SLIFLVYTLFLKYRIRLR 515
            ..:|:.:| ::.|.|. |.::||    .|:|: |..|:|...:::
  Rat   486 WYQYHSLD-VIGFLLTCFAVIAALTVKCLLFM-YRFFVKKEKKMK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	107/492 (22%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	118/526 (22%)
Ugt2b	NP_113721.5	UDPGT	24..527	CDD:278624	121/546 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810