DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B1 and Ugt1a1

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_036815.1	Gene:	Ugt1a1 / 24861	RGDID:	3935	Length:	535	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	129/539 - (23%)
Similarity:	236/539 - (43%)	Gaps:	78/539 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CWLTLSLCLLL--QHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDIE 68
            |.|.|..||||  ....|..|..|.:.|... |.:..|..:::.|..:||.|.:|.|....:..|
  Rat     9 CSLLLLPCLLLCVLGPSASHAGKLLVIPIDG-SHWLSMLGVIQQLQQKGHEVVVIAPEASIHIKE 72

  Fly    69 G----VRHIRVAQLNERI--------KEMLESDQVLDFMINKWTESALTAKALFNASNDILSDPG 121
            |    :|...|...||.:        :.:.:.|..|..::..:.:....:..|.:         |
  Rat    73 GSFYTMRKYPVPFQNENVTAAFVELGRSVFDQDPFLLRVVKTYNKVKRDSSMLLS---------G 128

  Fly   122 VQRMLHD-------KSESFDLIIMEP-----------SSLDALYGLVEFYNATLMGLSSIRINWH 168
            ...:||:       :...||.::.:|           .||.|:|    |.||....|.
  Rat   129 CSHLLHNAEFMASLEQSHFDALLTDPFLPCGSIVAQYLSLPAVY----FLNALPCSLD------- 182

  Fly   169 TYELAGNPAPSIYEPISPVGFSLETSLFSRVYNWIHIMEEKLVNYLILRPAQLHLFQKFFGYSA- 232
             .|....|||..|.|.|....:...:...||.|.|..:.|..:..::..|         :|..|
  Rat   183 -LEATQCPAPLSYVPKSLSSNTDRMNFLQRVKNMIIALTENFLCRVVYSP---------YGSLAT 237

  Fly   233 ---QK---MNELRSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLD-KAD 290
               ||   :.:|.|..|:.|:.:.:.....|...||::.:||::..:....| :|.:.::: ..:
  Rat   238 EILQKEVTVKDLLSPASIWLMRNDFVKDYPRPIMPNMVFIGGINCLQKKALS-QEFEAYVNASGE 301

  Fly   291 HGVIYFSMGNDILIKFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVVEQAPQRHILN 355
            ||::.||:|:  ::..:||.....:.:....:.::::|:.......:.:.|..:|:..||..:|.
  Rat   302 HGIVVFSLGS--MVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLG 364

  Fly   356 HPNVRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETI 420
            ||..|.|||:.|...:.|.:.:||||:.:|:|.||..|.:.::..|....:::..:..|.|...:
  Rat   365 HPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENAL 429

  Fly   421 KHMLANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSI 485
            |.::.|.||......:|...||||:.|||.||:|.||.:|::....:|....::...:|:.:| :
  Rat   430 KTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLD-V 493

  Fly   486 LAFSLRFGLVAASLIFLVY 504
            :.|.|   .:..:::|:||
  Rat   494 IGFLL---AIVLTVVFIVY 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	114/478 (24%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	117/502 (23%)
Ugt1a1	NP_036815.1	UDPGT	30..526	CDD:278624	120/518 (23%)
Ugt1a1	NP_036815.1	egt	<263..509	CDD:223071	64/252 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.710