DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B1 and Ugt3a2

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_659094.1	Gene:	Ugt3a2 / 223337	MGIID:	2145969	Length:	523	Species:	Mus musculus

Alignment Length:	553	Identity:	130/553 - (23%)
Similarity:	239/553 - (43%)	Gaps:	82/553 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WLTLSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDIEGVR 71
            ||.:|. |.|:....:||.||.|... ..|.:.|:..:.:.|...|||||
Mouse     7 WLLMSF-LFLEVILLEAAKILTISTL-SASHYIVISRVSQVLHEGGHNVT--------------- 54

  Fly    72 HIRVAQLNERIKEMLESDQVLDFMINK-------W------------TESALTAKALFNAS---- 113
                       |.:.||..:.||...|       |            ....||.:..:..|
Mouse    55 -----------KLLYESANIPDFRKEKPSYQVINWRPPEDQEKKFADLRHRLTEEITYGRSKHHT 108

  Fly   114 ------------NDILSDPGVQRMLHDKSESFDLIIMEPSSLDALYGLVEFYNATLMGLSSIRIN 166
                        :.:||...:...|  |:|:|||::::...|.:|. :||......:.....:.:
Mouse   109 LLKIHQYFGDLCSQLLSRKDIMDFL--KNENFDLVLLDSMDLCSLL-IVEKLGKRFVSFLPFQFS 170

  Fly   167 WHTYELAGNPAPSIYEPISPVGFSLETSLFSRVYNWIHIMEEKLVNYLILRPAQLHLFQKFFGYS 231
            :..:.|..  ||..|.|:...|.:.:...:.||.|::..::..:....||......:.:.|...|
Mouse   171 YMDFGLPS--APLSYAPVYGSGLTDQMDFWGRVKNFLMFLDFSMKQREILSQYDSTIQEHFVEGS 233

  Fly   232 AQKMNELRSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDK-ADHGVIY 295
            ...:::|..:..|..:||.:::...|...||.:.|||| |.:|.:|..::|:.|:.: .|.|.:.
Mouse   234 QPVLSDLLLKAELWFVNSDFALDFARPLFPNTVYVGGL-LDKPVQPIPQDLENFISQFGDSGFVL 297

  Fly   296 FSMGNDILIKFLPENIQELLLQTFATLNESIIWKSELLYMP---DKSDNVYVVEQAPQRHILNHP 357
            .::|:.:.:....|.|:| :...||.|.:.::|..:..:.|   ..:.||.:::..||..:|.||
Mouse   298 VALGSIVSMIQSKEIIKE-MNSAFAHLPQGVLWTCKTSHWPKDVSLAPNVKIMDWLPQTDLLAHP 361

  Fly   358 NVRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKH 422
            ::|||:|:||:.||:|||..||||:|:|.||||..||..|:...:...:.:.:|..::...|:|.
Mouse   362 SIRLFVTHGGMNSVMEAVHHGVPMVGIPFFFDQPENMVRVEAKNLGVSIQLQTLKAESFALTMKK 426

  Fly   423 MLANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILA 487
            ::.:..|...|..........|::|....:.|.::.|:......::....:.|..|.|.:|   .
Mouse   427 IIEDKRYKSAAMASKIIRHSHPLTPAQRLLGWIDHILQTGGAAHLKPYAFQQPWHEQYMLD---V 488

  Fly   488 FSLRFGLVAASL-----IFLVYTLFLKYRIRLR 515
            |....||:..:|     :.:..|.:|....:::
Mouse   489 FLFLLGLMLGTLWLSVKVLVAVTRYLSIATKVK 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	115/479 (24%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	118/513 (23%)
Ugt3a2	NP_659094.1	UDPGT	23..488	CDD:278624	118/501 (24%)
Ugt3a2	NP_659094.1	egt	<235..488	CDD:223071	71/257 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840578
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740