DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B1 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_038729.1	Gene:	Ugt1a2 / 22236	MGIID:	3576049	Length:	533	Species:	Mus musculus

Alignment Length:	529	Identity:	128/529 - (24%)
Similarity:	240/529 - (45%)	Gaps:	68/529 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTLSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDIEG--- 69
            |.|.||.|   ..|:.|.:| :.|... |.:..|:.:||.|..|||. |::....:...|:|
Mouse    15 LLLLLCAL---PWAEGAKVL-VLPMEG-SQWLSMRDVVRELHARGHQ-TVVLASEVTVHIKGEDF 73

  Fly    70 --VRHIRVAQLNERIKEMLESDQVLDFMINKWTESALTAKALFNASN------DILSDPGVQRML 126
              ::........|..::.:.||      |.|..::....||.|..:.      |:.|:..: .:|
Mouse    74 FTLKTYAFPYTKEEYQQEILSD------IEKTFKTQHFVKAFFETTASIRNFFDLYSNSCI-ALL 131

  Fly   127 HDK-------SESFDLIIMEP----SSLDALYGLVEFYNATLMGLSSIRINWHTYELAGNPAPSI 180
            |:|       |..||:|:.:|    .::.|.|  ::.....::...|..|.   ||....|.||.
Mouse   132 HNKMLIQQLNSSFFDVILTDPIFPCGAVLAKY--LQIPAVFILRSLSCGIE---YEATQCPNPSS 191

  Fly   181 YEPISPVGFSLETSLFSRVYNWIHIMEEKLVNYLILRPAQLHLFQKFFGYSAQKMNELRSRFSLM 245
            |.|......|.......||.|.::.:..|.:..|.:.|           |.:.....|:...||:
Mouse   192 YIPNLLTRLSDHMDFLQRVQNMLYYLVLKYICRLSITP-----------YESLASELLQREVSLV 245

  Fly   246 LINSHYSMGKVRAN---------APNIIEVGGLHLSEPPEPSDEELQKFLD-KADHGVIYFSMGN 300
            .:.||.|:...|.:         .||::.:||:: ....:|..:|.:.::: ..:||::.||:|:
Mouse   246 EVLSHASVWLFRGDFVLDYPRPIMPNMVFIGGIN-CVTKKPLSQEFEAYVNASGEHGIVVFSLGS 309

  Fly   301 DILIKFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVVEQAPQRHILNHPNVRLFITN 365
              ::..:||.....:.:....:.::::|:.......:.:.|..:|:..||..:|.||..|.|||:
Mouse   310 --MVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITH 372

  Fly   366 GGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLANNSYY 430
            .|...:.|.:.:||||:.:|:|.||..|.:.::..|....:::..:..|.|...:|.::.|.||.
Mouse   373 SGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYK 437

  Fly   431 LKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSLRFGLV 495
            .....:|...||||:.|||.||:|.||.:|::....:|....::...:|:.:| ::.|.|   .:
Mouse   438 ENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLD-VIGFLL---AI 498

  Fly   496 AASLIFLVY 504
            ..:::|:|:
Mouse   499 VLTVVFIVF 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	116/472 (25%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	118/496 (24%)
Ugt1a2	NP_038729.1	UDPGT	28..524	CDD:278624	122/513 (24%)
		Glycosyltransferase_GTB_type	43..>175	CDD:299143	30/141 (21%)
		egt	<261..505	CDD:223071	62/250 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840626
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.640