DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B1 and ugt-16

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_506210.1	Gene:	ugt-16 / 191171	WormBaseID:	WBGene00013901	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	551	Identity:	128/551 - (23%)
Similarity:	225/551 - (40%)	Gaps:	108/551 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGM--PNDIEGVRHI---------- 73
            |..||.||     .||..         |...|::||::.||.:  ..::.|.:.:
Worm    29 ASHANFLG-----KISDI---------LIDAGNDVTMLIPIFVNGKKELVGSKKVKKIIRIDQDP 79

  Fly    74 RVAQLN-----ERI--KEMLESDQVLDFM---INKWTESALTAKALFNASNDILSDPGVQRMLHD 128
            |:||::     |.|  |.:.:.|..:..|   |..::::|...........:::...
Worm    80 RIAQIHKEGSTEEIMRKTIWKMDSAITSMFGFIGNFSKTAAYQTEYMFQQTELIEQL-------- 136

  Fly   129 KSESFDLIIMEPSSLDAL-----YGLVEFYNA--TLM--GLSSIRINWHTYELAGNPAPSIYEPI 184
            :.|.|||.|.|...|.|.     .|:....||  ||.  |:..         ..|.||...|.|.
Worm   137 RKEKFDLAITESLFLGAFALFDEIGIRSVINADSTLYMGGMKG---------ALGEPAAISYYPG 192

  Fly   185 SPVGFSLETSLFSRVYN--------WIHIM--EEKLVNYLILRPAQLHLFQKFFGYSAQKMNELR 239
            .......:.:.|.||.|        |..::  ::::|           .|.|.: ..::...|..
Worm   193 LFSSIDDKMNFFGRVKNAVGYLFGLWFSVLKYDDEIV-----------AFPKSY-KGSRDWREHL 245

  Fly   240 SRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDKADHGVIYFSMGNDILI 304
            |..:...|||:..:.......|..:.|||:.::     :.:..:..|.|..:.|:.....| :|:
Worm   246 SNVAFNFINSNQYIDYASPTLPKTVFVGGMQVN-----TKKSGKSTLSKEWNDVLSLRKTN-VLV 304

  Fly   305 KF--------LPENIQELLLQTFATLNE-SIIWKSEL--LYMPDKSDNVYVVEQAPQRHILNHPN 358
            .|        :|:..::..|:.||::.| :.|||.|:  ..:.|...||.:....||..||....
Worm   305 SFGSNAYSSDMPDEFKKSFLEVFASMPETTFIWKYEVANATLVDHLPNVKLTTWMPQNDILADDR 369

  Fly   359 VRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSL-NKDTLTETIKH 422
            :.||||:|||.|.:|....|.|.:.:|:..||..|...:...|.|..:|...| |.:.|.|.|:.
Worm   370 LTLFITHGGLGSSVELAYQGKPAVVIPLMADQPRNAHMLTRHGGALQLDKTWLNNSEKLREAIQT 434

  Fly   423 MLANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILA 487
            :|.:.||...|:.:::..:|:|..|.|..:...::|::...:..:......:...:||.:|.:||
Worm   435 VLNDVSYKHNAERLAKILEDQPHKPKDVVLKHCDFAVQFGPLDTLNSEGRLLNTFQYYSVDIVLA 499

  Fly   488 FSLRFGLVAASLIFLVYTLFLKYRIR-LRRL 517
            ..    ::.:.::|:|| |.:|...| |.||
Worm   500 IF----VILSVILFVVY-LVIKLLFRFLGRL 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	114/493 (23%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	117/522 (22%)
ugt-16	NP_506210.1	UDPGT	19..532	CDD:278624	128/551 (23%)
		egt	<246..503	CDD:223071	67/266 (25%)
		HemY_N	483..>531	CDD:284604	14/48 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860