DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B1 and ugt-43

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001255487.1	Gene:	ugt-43 / 184052	WormBaseID:	WBGene00008485	Length:	540	Species:	Caenorhabditis elegans

Alignment Length:	568	Identity:	133/568 - (23%)
Similarity:	226/568 - (39%)	Gaps:	90/568 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLRYCWLTL----SLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPI 61
            |....|...|    |.|..:.:: .:...:|...|....|....|......|...|:||||:.|:
Worm     1 MNFTICSFLLLILASFCFSVSNN-IKGKKVLVYLPVTGHSHLKFMSTTSNILQEEGYNVTLLLPL 64

  Fly    62 GMPNDIEGVRHIRVAQLNERIKEMLESD---QVLDFMI---------NKWTE----------SAL 104
                 |:...:.....:.::||..:..|   .|:..:|         ..||.          |.|
Worm    65 -----IDITLNNTNIPIVKKIKHRINLDIHPGVMRTIIKMGGMASRRQTWTMGSGIYGFDGISHL 124

  Fly   105 TAKALFNASNDILSDPGVQRMLHDKSESFDLIIMEP------SSLDALYGLVEFYNA-TLMGLSS 162
            .:....|..::|...||:...|  |:|.:::.:.||      :..|.| |:.:..:. :.:||..
Worm   125 LSDLYSNICDNIFHMPGLLDRL--KAEKYEMGMSEPFFVCGFALFDHL-GIDKIISVDSHIGLEG 186

  Fly   163 IRINWHTYELAGNPAPSIYEPISPVGFSLETSLFSRVYNWIHIMEEKLVNYLILRPAQLHLFQK- 226
            .:|      ..|.|..|.|   .|..||..:...|.|.....:.|    .||..:.|:| :..|
Worm   187 PKI------AHGFPVTSSY---LPAAFSESSDHMSFVERTRSLYE----TYLNRKFARL-IHNKE 237

  Fly   227 -------FFGYSAQKMNELRSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQK 284
                   :.|.|.  ..||....:.|..||:..:..........||:||:...|  :..||.|.:
Worm   238 IDAMKGVYKGKST--WEELMRLPAYMFTNSNPILDFPYPRPSKFIEIGGIAADE--KKHDEVLPE 298

  Fly   285 FLD---KADHGVIYFSMGNDILIKFLPENIQELLLQTFATLNE-SIIWKSE------LLYMPDKS 339
            ..|   ...:..:..|.|::....|:|::::..|:.....:.: :.|||.|      :.......
Worm   299 SYDHILNLRNRTVLISFGSNAKSIFMPDHMRRSLIIALGMMPDITFIWKYENSSIDIVKEFDPTI 363

  Fly   340 DNVYVVEQAPQRHILNHPNVRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAE 404
            .|:..|:..||:.:|..|.:.||:|:||:.|..|...||.|.:.:|:|.||..|.|.::..|
Worm   364 KNIVQVDWMPQQALLADPRLDLFVTHGGMASTNEIAFSGKPAVMVPVFGDQTRNSRMLERHG--- 425

  Fly   405 VMDINSLNKDTL------TETIKHMLANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRN 463
              .:..|.|:.|      .|||..:|.:.||..:|::::...::.|.||....:.:..:..|...
Worm   426 --GVLMLRKENLEYPEIVIETILSVLNDPSYAERAQQLATLLRNHPESPKQVFLKYFNFVARFGK 488

  Fly   464 ITRMRLNLEEIPLIEYYRIDSILAFSLRFGLVAASLIFLVYTLFLKYR 511
            .|.:..|...:..|.||.:| ::||.|.....|..|:..||:.|...|
Worm   489 PTGIDSNSINVDFIAYYYLD-LIAFLLIVAYFAKFLVSHVYSYFCYLR 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	113/493 (23%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	124/522 (24%)
ugt-43	NP_001255487.1	Glycosyltransferase_GTB_type	<215..517	CDD:299143	77/316 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.860