DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B1 and ugt-66

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_498344.3	Gene:	ugt-66 / 182814	WormBaseID:	WBGene00016013	Length:	532	Species:	Caenorhabditis elegans

Alignment Length:	555	Identity:	131/555 - (23%)
Similarity:	219/555 - (39%)	Gaps:	80/555 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTLSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDIEGVRH 72
            :.|.|..|...::....|:|.:.|....|....|..|..||...|||||.:.|:        ...
Worm     2 IRLHLLFLFLINQTLTINVLVLSPAFGGSHMNFMAHLADTLTEAGHNVTFLIPV--------ADE 58

  Fly    73 IRVAQLNERIKE---MLESDQVL--------DFMINKWT--ESALTAKALFNASNDI-------- 116
            .|..||..:|.:   ::|.|:::        |.|...||  ......:.:|:..|.|
Worm    59 TRKNQLGVKITKDVVLVEQDEIMSRDTLIVDDHMDMMWTLDTHEPNFEEMFSWFNKIMELSCANF 123

  Fly   117 LSDPGVQRMLHDKSESFDLIIMEPSSLDALYGLVEFYNATLMGLSSIRINWHTYEL----AGNPA 177
            |.:..|..::  ||.:||:.|:||.|:..|    .|:....:..:.:..:...|:.    .|.|.
Worm   124 LRNTEVFELM--KSRNFDVAILEPLSVCGL----GFFKKLGIEKTILASSCSLYDFILPDIGEPE 182

  Fly   178 PSIYEPISPVGFSLETSLFSRVYNWIHIMEEKL-VNYLILRPAQLHLFQKFFGYSAQKMNELRSR 241
            ...|.|........:.|.:.|..|:....:.|: ::.:..|  :..:::...|........|...
Worm   183 DHSYVPSLSSQSGDQMSFYERYKNYRFSRDTKVTMDRMFDR--ETAIYRAHLGKDLPDWRVLLPS 245

  Fly   242 FSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDKADHGVIYFSMGNDILIKF 306
            .||...||:..:...|......:.:||:.::.....|    ||..|..|  ||.....|::||.|
Worm   246 ASLFFTNSNPYLDFPRPVIQKTVAIGGISVNMGKIKS----QKLDDHWD--VILDQRNNNMLISF 304

  Fly   307 --------LPENIQELLLQTF-ATLNESIIWKSEL--LYMPDKSDNVYVVEQAPQRHILNHPNVR 360
                    :|.:.:..:|:.. :..|.:.|||.|.  ....|..|||:..:..||..:||...:.
Worm   305 GSMVKSSTMPIDWKMNILKVIKSEPNVTFIWKYETNDTKFADGVDNVHFSKWVPQTALLNDDRLT 369

  Fly   361 LFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSL-NKDTLTETIKHML 424
            .|:|:|||.|..|....|.|.:.:|:|.||..|...:.....|..:..|.| |...:.|.:..:|
Worm   370 AFLTHGGLGSTNELAHWGKPAVTVPIFGDQVRNANMLTRHNGAIFVWKNDLGNYGIVKEAVHQIL 434

  Fly   425 ANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALR----------NRNITRMRLNLEEIPLIEY 479
            .|..|...||.::...:::|..|.|..|..||:..:          .|::.....||
Worm   435 YNEKYKRNAKYLADILENQPHQPKDLVVKHTEFLAKFGPFPKMDPYGRSLNFFTRNL-------- 491

  Fly   480 YRIDSILAFSLRFGLVAASLIFLVYTLFLKYRIRL 514
            :.|.:.:.|:. |.|..||...|.: |..|:.|:|
Worm   492 FDIHAAVVFTY-FILATASFNILKF-LLSKFSIKL 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	114/488 (23%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	122/517 (24%)
ugt-66	NP_498344.3	UDPGT	22..530	CDD:278624	126/535 (24%)
		Glycosyltransferase_GTB_type	23..>54	CDD:299143	11/30 (37%)
		Glycosyltransferase_GTB_type	<222..477	CDD:299143	66/262 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950