DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B1 and ugt-50

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_741913.1	Gene:	ugt-50 / 181413	WormBaseID:	WBGene00011564	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	554	Identity:	136/554 - (24%)
Similarity:	232/554 - (41%)	Gaps:	94/554 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WLTLSLCLLLQHDR--AQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITP--IGMPNDI 67
            |:...|..|| |..  ..||.||...|....|...:.......|...||:..|..|  ..:.::.
Worm     8 WMFFCLTALL-HGSFIVNAAKILVYCPSISKSHVLLCSKYADLLHNAGHDTVLFIPSYSKLLDNY 71

  Fly    68 EGVRHIRVAQLNE----------RIKEMLESDQV-----LDFMINKWTESALTAKALFNASNDIL 117
            :|.:|.:|.:|:.          .:..::|:..:     |.|..:.|.:...          |:|
Worm    72 DGAKHAKVWRLHNVTEAYDTKLGTLANVMENSHIGFIDRLTFDADFWIDMCA----------DLL 126

  Fly   118 SD-PGVQRMLHDKSESFDLII---MEPSSLDALYGLVEFYNATLMGLSSI--RINWHTYELAGNP 176
            .. |.:|.::..|   |||:|   ::|.: .|:..|.......|:...:|  ::.|:    .|.|
Worm   127 GKLPEMQHIIDYK---FDLVIYNEIDPCT-PAIVRLFNIPKTVLLSSEAIMDKVAWN----LGLP 183

  Fly   177 APSIYEPISPVGFSLE-------TSLFSRVYNWIHIMEEKLVNYLILRPAQ----LHLFQKFFGY 230
            ....|.|      |:|       .|.|.|:.|.....:..:|:||     |    |:||:|....
Worm   184 TLPSYVP------SVEENPNHDRMSFFERMSNVYKFFQSIVVHYL-----QDIHVLNLFRKEVSS 237

  Fly   231 SAQKMNELRSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEP-----PEPSDEELQKFLDKAD 290
            ....:.|:....||:|:|:.......|:.:...:.||.|...:.     |:..|:    :..|..
Worm   238 DFPSIAEIIRNVSLVLVNTDEIFDLPRSYSSKFVYVGMLEAGKDENVTLPKKQDD----YFKKGK 298

  Fly   291 HGVIYFSMGNDILIKFLPENIQELLLQTFATLNE-SIIWKSELLYMPDKS--------DNVYVVE 346
            .|.::.|.|.....:.|||.||..:|.....|.: ..:.|:.   ..|:|        .||.:|:
Worm   299 SGSVFVSFGTVTPFRSLPERIQLSILNAIQKLPDYHFVVKTT---ADDESSAQFFSTVQNVDLVD 360

  Fly   347 QAPQRHILNHPNVRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSL 411
            ..||:.:|.|.|::||:::||:.||:|.:..||||:.:|:|.|||.|.|.|:..|..:::...::
Worm   361 WVPQKAVLRHANLKLFVSHGGMNSVLETMYYGVPMVIMPVFTDQFRNGRNVERRGAGKMVLRETV 425

  Fly   412 NKDTLTETIKHMLANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPL 476
            .|:|..:.|..:|...||....|.||...|::|.:..:....|.::.|:........|....:.:
Worm   426 VKETFFDAIHSVLEEKSYSSSVKRISHLMKNKPFTSEERVTKWIDFVLKYETSEHFDLESNNLSI 490

  Fly   477 IEYYRIDSILAFSLRFGLVAASLI-FLVYTLFLK 509
            ||:..:|      |.|.|...||: |:||....|
Worm   491 IEHNHLD------LFFYLCIISLLNFVVYRKIFK 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	118/488 (24%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	125/518 (24%)
ugt-50	NP_741913.1	egt	9..475	CDD:223071	122/502 (24%)
ugt-50	NP_741913.1	UDPGT	26..520	CDD:278624	130/535 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810