DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B1 and ugt-6

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001369960.1	Gene:	ugt-6 / 179755	WormBaseID:	WBGene00013904	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	575	Identity:	129/575 - (22%)
Similarity:	236/575 - (41%)	Gaps:	116/575 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTLSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDIEGVRH 72
            :.|.|.:......|.:...|.|.|....|....|..|...||..|::||...|..:.   |...|
Worm     4 IVLFLFISTLFGNAYSYKFLVISPVYGFSHMKYMAELANHLARAGNDVTYFQPFVVD---EYHDH 65

  Fly    73 IRVAQLNERI---------KEMLESDQVL-DFMINKWTES-----ALTAKALFNASNDILSDPGV 122
            ..:.:.:.:|         ::.:.|...: |...:.|.:|     .|.:|.||.|...:     .
Worm    66 TLIKEKSIKIWNYYHDELGRQHIPSQGCMRDAWHSSWYQSDAGAAILLSKYLFPAFEHM-----C 125

  Fly   123 QRMLHD-------KSESFDLIIMEPSSLDALYGLVEFYNATLMGLSSI-------RINWHTYELA 173
            ::|..|       ||..||:::.|      .:.....|.|:.:.:.||       |:|    .||
Worm   126 RKMFEDTELHYDLKSRQFDVVLSE------AFDFCGLYLASYLEMPSIISTFTGNRLN----ALA 180

  Fly   174 ---GNPAPSIYEPISPVGFSLETSLFSRVYN-WIHIMEEKLVNYLILRPAQLHLFQKFFGYSAQK 234
               |.|:...|.|.....:..|:::|.|:.: |..|...             :.|.:.|....|:
Worm   181 PVLGEPSFLHYLPAPTSQYGHESTIFDRLNDVWHKIWSS-------------YGFAQLFEMQYQQ 232

  Fly   235 MNELRS---------------RFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSD----E 280
            :::|.:               .||    ||:..:..|....|.::.:||:.:......::    |
Worm   233 VSKLTNGKVKHWKDIIHDVTYHFS----NSNPYLDFVIPTIPKVVPIGGITVDHDYWSTNGNHSE 293

  Fly   281 ELQKFLDKADHGVIYFSMGNDILIKFLPENIQELLLQTFAT-LNESIIWKSELLYMPDKSD---- 340
            .|:..|:...|.| :.|.|:.:....:|:..::.:::.|:. .|.:.:||.||   |:..:
Worm   294 LLEHVLNARKHNV-FISFGSMVRSVDMPKEFKKSMMKVFSDHPNITFLWKYEL---PNDQEFLRI 354

  Fly   341 ---NVYVVEQAPQRHILNHPNVRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGM 402
               ||:|.:...|..:|:...|.||:|:|||.|.:|...:..|.:.:|:|.||.||.:.::..|.
Worm   355 LPTNVHVAKWFSQSALLSDQRVNLFVTHGGLGSTMELARAAKPAIVIPLFADQPGNAKMIERHGS 419

  Fly   403 AEV---MDINSLNKDTLTETIKHMLANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNI 464
            .|:   :||.  |...|:..|:.||....|...|..::...:.:|::|.|..|...|.|.|...:
Worm   420 VEIFSKLDIP--NSKKLSSLIQKMLNTKYYQQNANRLADTLRFQPITPTDLMVKHAENAARFGKM 482

  Fly   465 TRMRLNLEEIPLIEYYRIDSILAFSLRFGLVAASLIFLVYT----LFLKYRIRLR 515
            ..:..:.:::...|||.||.|....|        |::|:::    :|.|.::.|:
Worm   483 PNLVPHAKDMGFFEYYNIDIIFIVFL--------LVWLLFSVVAHVFSKLKLSLK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	115/503 (23%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	121/536 (23%)
ugt-6	NP_001369960.1	GT1_Gtf-like	20..456	CDD:340817	107/476 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810