DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B1 and ugt-11

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_504311.1	Gene:	ugt-11 / 178882	WormBaseID:	WBGene00020593	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	137/560 - (24%)
Similarity:	242/560 - (43%)	Gaps:	81/560 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLRYCWLTLS-LCLLLQHDRAQAANIL---GIFPYRHISPFFVMQPLVRTLATRGHNVTLITPI 61
            |||    ||.| ||.||:.:  .||.||   .||.:.|:.  ||.: |...:|..|..|||..|.
Worm     1 MRL----LTFSCLCFLLKVN--YAAKILIFNPIFGFSHVK--FVSK-LADIIADHGQEVTLFQPF 56

  Fly    62 GMP-NDIEGV---RHIRVA-----QLNERIKEMLESDQVLDFMINKWTESALTAKALF------- 110
            .:. .:::|:   ::|.:.     ..::.:|  ||:....||    |....:....|.
Worm    57 HLALKNLDGIVKNKNIEIINYYPDHYDDLLK--LETQTFPDF----WDSQLMNNPVLMAFMLPRI 115

  Fly   111 ------NASNDILSDPGVQRMLHDKSESFDLIIMEPSSLDALYGLVEFYNATLMG-LSSIRINWH 168
                  ..:..::.|..:.:.|.||  .||:.|.|...|..:| :..|.....:. ||::|::..
Worm   116 LGGEFKKTTIQLIKDKEILKKLKDK--KFDVAISETFELTGMY-MSHFLGVPCIPILSAVRLDIF 177

  Fly   169 TYELAGNPAPSIYEPISPVGFSL--ETSLFSRVYNWIHIMEEKLVNYLILRPAQLHLFQKFFGYS 231
            . |..|.  .|.:..::..|..|  :.....|:.:.......|:. :..:...|..:.:|..|:.
Worm   178 N-EAFGQ--SSAFGYLTQQGSKLAPDAGFLDRLNDVYRDFFSKMA-FRGMAQYQNDVIEKAAGHV 238

  Fly   232 AQKMNELRSRFSLMLINSHYSMGKVRANAPNIIEVGGL--------HLSEPPEPSDEELQKFLDK 288
            .....:|.....:.:.||:..:.........|:.:||:        |:...|    ||.:..| |
Worm   239 VPYWKDLVKEAPVYMTNSNPYLDFAVPTTATIVHIGGITINLEKMNHVDALP----EEYEIIL-K 298

  Fly   289 ADHGVIYFSMGNDILIKFLPENIQELLLQTFATLNESI-IWKSE---LLYMPDKSDNVYVVEQAP 349
            .....:..|.|:.|....:|||.:..|::.|.:|.:.| |||.|   |.:......||::.:..|
Worm   299 EKETTVLISFGSVIRSYEMPENFKAGLIKVFESLPDVIFIWKYEIDDLEFQKKLPKNVHLKKWVP 363

  Fly   350 QRHILNHPNVRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMD-INSLNK 413
            |..:|....|:||:|:|||.|.:|...:|.|.|.:|:|.||..|...:...|.|...| .:.::.
Worm   364 QPSLLADKRVKLFVTHGGLGSTMEVAYTGKPALMVPIFGDQPMNADMLARHGGAIAYDKFDLVDG 428

  Fly   414 DTLTETIKHMLANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIE 478
            ..||||::.::.|..|..||||:.....::|:.|:...:...|:|::..|:......:.::..|.
Worm   429 KKLTETVRDLVTNPKYEQKAKELLDVLTNQPIDPVMNLMKHLEFAIKFPNLRSQIPEINQVGPIA 493

  Fly   479 YYRIDSILAFSLRFGLVAASLIFL-VYTLFLKYRIRLRRL 517
            :|.:| ::.|          |||: :.|.::.::|..|.|
Worm   494 HYYLD-VIVF----------LIFVSIITAYISFQIVCRIL 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	115/481 (24%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	115/508 (23%)
ugt-11	NP_504311.1	egt	<220..514	CDD:223071	78/309 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810