DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B1 and ugt-45

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_500410.2	Gene:	ugt-45 / 177139	WormBaseID:	WBGene00021372	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	535	Identity:	131/535 - (24%)
Similarity:	223/535 - (41%)	Gaps:	57/535 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDIEGVRHIR 74
            |...||.....|....||...|....|....|..|...|...||:||.:.|:.:|....|....:
Worm     4 LVFLLLFVLPAASCYKILVSVPKFGFSHMQTMGKLADILVEAGHDVTFLMPVDVPIPQNGTELAK 68

  Fly    75 VA------QLNERIKEMLESDQVLDFMINKWTESALTAKALF------------NASNDILSDPG 121
            |.      .:||.:...::|..|    .|.||.||.:.:.:.            |..|.|.:...
Worm    69 VVLVPTTDAINEIMGHAMKSGAV----ANLWTHSANSKQGIMWSTDMIGQVSYHNTKNLIDNKAL 129

  Fly   122 VQRMLHDKSESFDLIIMEPSSLD--ALYGLVEFYNATLMGLSSIRINWHTYELAGNPAPSIYEPI 184
            ||:|   |.|.||:.|.|.....  |.:.::...|  :||..:..:...|....|.|....:.|.
Worm   130 VQQM---KDEKFDIGITELFDFSGLAFFEVIGLKN--VMGAHTTSVFEGTLMATGAPILPSFVPA 189

  Fly   185 SPVGFSLETSLFSRVYN-----WIHIMEEKLVNYLILRPAQLHLFQKFFGYSAQKMNELRSRFSL 244
            |........|:.||:.|     |.:..:.|:.::     ||..|.:.:....|.|:..|.|..:.
Worm   190 SQTFTDDSGSILSRLNNLYMTYWSYQFQNKIQSF-----AQKALDEHYEKGKAPKIWNLVSDITW 249

  Fly   245 MLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDKADHGVIYFSMGNDILIKFLPE 309
            ..:||.......:....||:|:.|:.:.| .:|..:|..:.|.|....|: .|.|:......:||
Worm   250 FFVNSDPIFDFPKPLPQNIVEIAGISVPE-IKPVGKEWDEILSKRSKNVL-VSFGSIASPTTMPE 312

  Fly   310 NIQELLLQTFATLNE-SIIWKSELLYMPDKS------DNVYVVEQAPQRHILNHPNVRLFITNGG 367
            .:::.::..||...: :.|||    |...:|      |||::|:..||..:|....:.:|.|:||
Worm   313 AVKKSIVDAFAAFPDVTFIWK----YDDTESKLTAHLDNVHIVKWMPQNDLLADKRISMFWTHGG 373

  Fly   368 LLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMA---EVMDINSLNKDTLTETIKHMLANNSY 429
            :.|::|:....||::.:|:|.||..|.:..:..|:|   :.||:::..|  |...:|.:|.|..|
Worm   374 MGSLMESAQKSVPLVVVPIFGDQMRNAQIAKRHGVALIYDKMDLSNTKK--LIGALKEVLENPEY 436

  Fly   430 YLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSLRFGL 494
            ...|:.:::.......||....:...|.|.|...:.|.....:|...::|:.:|.::.....|.|
Worm   437 KKSAELLARILATERFSPRQKIIDTVEMAGRFGQMPRWTSAGKEFSFLKYFNLDLVIIAVFIFFL 501

  Fly   495 VAASLIFLVYTLFLK 509
            ...|.:.|:..|..|
Worm   502 SIVSTVLLIRHLLAK 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	118/475 (25%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	123/504 (24%)
ugt-45	NP_500410.2	egt	14..513	CDD:223071	126/520 (24%)
ugt-45	NP_500410.2	UDPGT	19..510	CDD:278624	124/512 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14613
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860