Protein Alignment Ugt303B1 and UGT2A1

DIOPT Version :9

• Sequence 1: NP_651153.1
• Gene: Ugt303B1 / 42775
• FlyBaseID: FBgn0039086
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 122/500 - (24%)
• Similarity: 229/500 - (45%)
• Gaps: 72/500 - (14%)

  Fly    44 LVRTLATRGHNVTLITPIGM------PNDIEGVRHIRVAQLNERIKEMLESDQVLDFMINKWTE- 101
            ::..|..|.||||::.....      |:.......|.|:.....|      |.:::.||..|.:
Human   249 ILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNI------DSLIEHMIMLWIDH 307

  Fly   102 --SALTAKALF---------------NASNDILSDPGVQRMLHDKSESFDLIIMEP----SSLDA 145
              :.||..|.:               ...:.:|.:|.:...|  :...||:::.:|    ..|.|
Human   308 RPTPLTIWAFYKELGKLLDTFFQINIQLCDGVLKNPKLMARL--QKGGFDVLVADPVTICGDLVA 370

  Fly   146 L-YGLVEFYNATLMGLSSIRINWHTYELAGNPAPSIYEPISPVGFSLETSLFSRVYNWIHIMEEK 209
            | .|:...|  ||....:..:..|..::   |||..|.|.:....:.:.:...|:.|
Human   371 LKLGIPFMY--TLRFSPASTVERHCGKI---PAPVSYVPAALSELTDQMTFGERIKN-------- 422

  Fly   210 LVNYLILRPAQLHLFQKFFG-----YS-----AQKMNELRSRFSLMLINSHYSMGKVRANAPNII 264
            .::|.:    |.::||.::|     ||     ...:.|...:..:.||.:::.....|...||..
Human   423 TISYSL----QDYIFQSYWGEWNSYYSKILGRPTTLCETMGKAEIWLIRTYWDFEFPRPYLPNFE 483

  Fly   265 EVGGLHLSEPPEPSDEELQKFLDKA-DHGVIYFSMGNDILIKFLPENIQELLLQTFATLNESIIW 328
            .||||| .:|.:|..:|:::|:..: .:||:.||:|:  ::|.|.|....|:....|.:.:.::|
Human   484 FVGGLH-CKPAKPLPKEMEEFIQSSGKNGVVVFSLGS--MVKNLTEEKANLIASALAQIPQKVLW 545

  Fly   329 KSELLYMPDKSDNVYVVEQAPQRHILNHPNVRLFITNGGLLSVIEAVDSGVPMLGLPMFFDQFGN 393
            :.:........:|..:.:..||..:|.||..:.|||:||...:.||:..||||:|:|||.||..|
Human   546 RYKGKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDN 610

  Fly   394 MRWVQLSGMAEVMDINSLNKDTLTETIKHMLANNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYA 458
            :..::..|.|..:::|::....|...::.::...||...|..:|:...|:|:.|||.||:|.|:.
Human   611 IAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFV 675

  Fly   459 LRNRNITRMRLNLEEIPLIEYYRIDSILAFSLRFGLVAASLIFLV 503
            :|::....:|:...::...:|:.:| ::.|.|   :...:.||||
Human   676 MRHKGAKHLRVAAHDLTWFQYHSLD-VIGFLL---VCVTTAIFLV 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	113/457 (25%)
		UDPGT	41..511	CDD:278624	121/499 (24%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	121/499 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150201
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.690