DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B1 and UGT2B11

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001064.1	Gene:	UGT2B11 / 10720	HGNCID:	12545	Length:	529	Species:	Homo sapiens

Alignment Length:	529	Identity:	119/529 - (22%)
Similarity:	234/529 - (44%)	Gaps:	100/529 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 YRHISPFFVMQPLVRTLATRGHNVTLITPIGM----PNDIEGVR-HIRVAQLNERIKEMLESDQV 91
            |.|   :..|:.:::.|..|||.||::.....    |||...:: .:....|.:     .|.:.:
Human    33 YSH---WMNMKTILKELVQRGHEVTVLASSASILFDPNDASTLKFEVYPTSLTK-----TEFENI 89

  Fly    92 LDFMINKWTESALTAKALF----------------NASNDILSDPGVQRMLHDKSESFDLIIMEP 140
            :...:.:|::....:..|:                |...|::|:..|.:.|.:  ..||::.
Human    90 IMQQVKRWSDIRKDSFWLYFSQEQEILWELYDIFRNFCKDVVSNKKVMKKLQE--SRFDIVF--- 149

  Fly   141 SSLDALYGLVEFYNATLMGLSSIRINWHTYELAGNPA------------PSIYEPISPVGFSLET 193
              .||::...|.    |..|.:||.   .|.|...|.            |..|.||.....|.:.
Human   150 --ADAVFPCGEL----LAALLNIRF---VYSLRFTPGYTIERHSGGLIFPPSYIPIVMSKLSDQM 205

  Fly   194 SLFSRVYNWIHIME-------------EKLVNYLILRPAQLHLFQKFFGYSAQKMNELRSRFSLM 245
            :...||.|.|:::.             ::..:.::.||..|.              |...:..:.
Human   206 TFMERVKNMIYVLYFDFWFQMSDMKKWDQFYSEVLGRPTTLF--------------ETMGKADIW 256

  Fly   246 LINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDKA-DHGVIYFSMGNDILIKFLPE 309
            |:.:.:|........||:..|||.| .:|.:|..:|:::|:..: ::||:.||:|:  :|..:..
Human   257 LMRNSWSFQFPHPFLPNVDFVGGFH-CKPAKPLPKEMEEFVQSSGENGVVVFSLGS--VISNMTA 318

  Fly   310 NIQELLLQTFATLNESIIWKSELLYMPDKSD----NVYVVEQAPQRHILNHPNVRLFITNGGLLS 370
            ....::....|.:.:.::|:    :..:|.|    |..:.:..||..:|.||..|.|||:||...
Human   319 ERANVIATALAKIPQKVLWR----FDGNKPDALGLNTRLYKWIPQNDLLGHPKTRAFITHGGANG 379

  Fly   371 VIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLANNSYYLKAKE 435
            :.||:..|:||:|:|:||||..|:..::..|.|..:|.|:::...|...:|.::.:..|.....:
Human   380 IYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRLDFNTMSSTDLLNALKTVINDPLYKENIMK 444

  Fly   436 ISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSLRFGLVAASLI 500
            :|:...|:|:.|||.||:|.|:.:.::....:|:...::...:|:.:| ::.|.|   ...|::|
Human   445 LSRIQHDQPVKPLDRAVFWIEFVMPHKGAKHLRVAAHDLTWFQYHSLD-VIGFLL---ACVATVI 505

  Fly   501 FLV--YTLF 507
            |::  :.||
Human   506 FIITKFCLF 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	109/480 (23%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	117/520 (23%)
UGT2B11	NP_001064.1	UDPGT	24..525	CDD:278624	119/529 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150491
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.690