DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B1 and ugt5b3

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001348442.1	Gene:	ugt5b3 / 100415792	ZFINID:	ZDB-GENE-100406-5	Length:	534	Species:	Danio rerio

Alignment Length:	545	Identity:	146/545 - (26%)
Similarity:	251/545 - (46%)	Gaps:	66/545 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 W-LTLSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLI------------ 58
            | :||:| ||:.....::.|:| :||. .:|.:..|..||..|..:|||:|::
Zfish    10 WPVTLTL-LLVTVPVVESGNVL-VFPV-DVSHWVNMNVLVEALHAKGHNITVMRMADSWYIKEFS 71

  Fly    59 ---TPIGMPNDIEGVRHIRVAQLNERIKEMLESDQV---LDFMINKWTESALTAKALFNASNDIL 117
               |.:.:.:. .|:....:.....|:..:|.....   |...|..|..|....:.......:::
Zfish    72 PHYTSVNLKSS-GGLSEDFIGPFVSRLMNILREGSTWGRLKLEIEMWQTSLKMIEIEREMITNMI 135

  Fly   118 SDPGVQRMLHDKSESFDLIIMEPSSLDALYG---------LVEFYNATLMGLSSIRINWHTY--- 170
            .|..:.:.|  |...||||:.:|    |:||         |...||          :.|..:
Zfish   136 EDQQLMQSL--KKAKFDLILTDP----AMYGGVMLGHYLKLPIVYN----------VRWTIFGEG 184

  Fly   171 ELAGNPAPSIYEPISPVGFSLETSLFSRVYNWI-HIMEEKLVNYLILRPAQLHLFQKFFGYSAQK 234
            ..|..|:|..|.|:..:......|...||.|.: :|:.|..:.:|| .|....|.::|.|... .
Zfish   185 HFAIAPSPLSYVPVPMLEIPDRMSFLERVKNVVMYIITETQIAFLI-APTYNALCERFIGPEV-N 247

  Fly   235 MNELRSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDKA-DHGVIYFSM 298
            ...|.....|.|..:.:.....|...|||:.:.|.. .:|.:|..::|:.|:..: |||||..|:
Zfish   248 FGNLVQEADLWLHRADFVFEYPRPTMPNIVYMAGFQ-CKPSKPLPQDLEDFVQSSGDHGVIVMSL 311

  Fly   299 GNDILIKFLPENIQELLLQTFATLNESIIWKSELLYMPDKSDNVYVVEQAPQRHILNHPNVRLFI 363
            |.  ||..||:::.|.:.:.||.|.:.|||:.:........:|..|::..||..:|.||..|.|:
Zfish   312 GT--LIGQLPDDVAEAIAEAFAELPQKIIWRYKGKRPSALGNNTLVMDWMPQNDLLGHPKTRAFV 374

  Fly   364 TNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLANNS 428
            .:||...|.||:..|||::|..:.|||..|:..:::.|.|:.:|..:::|::..:|:|.:|.:.|
Zfish   375 AHGGTNGVQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMDKESFLKTVKEVLYDPS 439

  Fly   429 YYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSLRFG 493
            |....:.:|:..||.|:.|||.|::|.|:.:|::....:|....::|...|:.:|.||..
Zfish   440 YRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVILVL----- 499

  Fly   494 LVAASLIFLVYTLFLKY---RIRLR 515
            :.|.|||.|.....::|   ||.:|
Zfish   500 ISAVSLIILSIYAVIRYFCCRICMR 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	125/472 (26%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	132/504 (26%)
ugt5b3	NP_001348442.1	UDPGT	27..531	CDD:278624	140/527 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584507
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.790