DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B1 and ugt2b5

DIOPT Version :9

Sequence 1:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001170816.2	Gene:	ugt2b5 / 100384902	ZFINID:	ZDB-GENE-100402-3	Length:	527	Species:	Danio rerio

Alignment Length:	537	Identity:	137/537 - (25%)
Similarity:	249/537 - (46%)	Gaps:	61/537 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLRYCWLTLSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIG--- 62
            |||..|:|:    ||......|..|||  ..|...|.:..::.::.||..||||||::.|.|
Zfish     1 MRLVVCFLS----LLTVFSAGQCGNIL--VWYTEGSHWINLKIVLDTLLDRGHNVTVLVPDGALF 59

  Fly    63 ---MPNDIEGVRHIRVAQLNERIKEMLESDQVLDFMINKWTESAL--TAKALFNASND------- 115
               ..:|....:|..|::..:.:::..  |:::.|.:.:...|:.  .....||..:.
Zfish    60 MKAKESDRFSYQHFSVSKSAQDMQDFF--DELMRFSVFEMDNSSFLEIQMKFFNLGSQHQDMSLS 122

  Fly   116 ----ILSDPGVQRMLHDKSESFDLIIMEPSSLDALYG----LVEFYNATLMGLSSIRINWHTYEL 172
                ||..|.:...|  |...||:::.:|     :|.    :.|..|..|:......:......:
Zfish   123 YCDGILKSPELMDKL--KKGKFDVVLSDP-----MYPCSDIVAEELNVPLVYTFRFSVAHAAERM 180

  Fly   173 AGN-PAPSIYEPISPVGFSLETSLFSRVYNWIHIMEEKLVNYLILRPAQLHLFQKFFGYSAQKMN 236
            .|. |||..|.|.:....:.:.|...|::|.:..:.:..::.||.|... :.:.::||.|....
Zfish   181 CGQIPAPPSYVPGAMSKLTDKMSFTERIFNMLFYLSQDTLSRLIWRRFD-NYYTEYFGRSTSYC- 243

  Fly   237 ELRSRFSLMLINSHYSMGKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDKA-DHGVIYFSMGN 300
            |:..:..:.||.:::.....|...||...:||||.: |.:|..:::::|:..: |.|::.|::|:
Zfish   244 EMMGKADIWLIRTYWDFEFPRPFVPNFKYIGGLHCT-PAKPLPKDMEEFVQSSGDDGIVVFTLGS 307

  Fly   301 DILIKFLPENIQELLLQTFATLNESIIWKSELLYMPDKSD----NVYVVEQAPQRHILNHPNVRL 361
              :|..:|:.:...:....|.:.:.::|:    |..:|.|    |..:.:..||..:|.||..|.
Zfish   308 --MIDKVPKEMSNRIASALAQIPQKVLWR----YGGEKPDTLGENTRIYKWIPQNDLLGHPKTRA 366

  Fly   362 FITNGGLLSVIEAVDSGVPMLGLPMFFDQFGNMRWVQLSGMAEVMD-INSLNKDTLTETIKHMLA 425
            |||:||...|.||:..||||:|:|:|.||..||..:.....|.|:| |.|:....|.:.:..::.
Zfish   367 FITHGGTNGVYEAIYHGVPMVGIPLFGDQPDNMVHMTTRAAAVVVDSIKSMQPQELVDKLNTVIN 431

  Fly   426 NNSYYLKAKEISQFFKDRPMSPLDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSL 490
            :.||...|..:|:...||||.|||.:|:|.|:.:||:....:|:....:...:|:.:|.
Zfish   432 DPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQYHCLDV------ 490

  Fly   491 RFGLVAASLIFLVYTLF 507
             |..:...|..::|..|
Zfish   491 -FAFLTTVLTLVLYICF 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	122/470 (26%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	124/497 (25%)
ugt2b5	NP_001170816.2	UDPGT	20..523	CDD:278624	129/514 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.860