DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B3 and ugt1b4

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001166239.2	Gene:	ugt1b4 / 795050	ZFINID:	ZDB-GENE-080227-13	Length:	533	Species:	Danio rerio

Alignment Length:	538	Identity:	134/538 - (24%)
Similarity:	238/538 - (44%)	Gaps:	105/538 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHLEFYWLAVLFCL--------FLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGH 57
            ||     |.|:.||        .:.:.|.::|.....:|.:  ....||...|:.:|:.:.:|||
Zfish     5 MH-----LGVIICLVVGVVCSAVVDQKLSRNSSWTGKLLVV--PMDGSHWTGVKAVAEEMGRRGH 62

  Fly    58 NVTLIT------------------PVGMPTDIEGVRHIRVPKLNQRVQEMIEGDQILDFFGSKWI 104
            .|.::.                  ||....|:  :..|.|    :.|.|:...:|.|    .|.:
Zfish    63 TVIVVIPEISMRLGPGKHYITKKFPVQYKQDL--INQIMV----EHVNEVAASEQSL----LKTV 117

  Fly   105 ASLM-----VVSMLYNMSSDILSDKGVQKMLQNRNERFDLVMLEPSALEALYGVVEHYNAT---- 160
            .|:|     ::....:.|..:..::.:.:.|:::|  ||.|:..|:   ...|.:..||.:
Zfish   118 TSIMYRFGKIIDHFISTSESLFQEQELIEFLRDQN--FDAVLTNPA---MPMGAILAYNLSVPAV 177

  Fly   161 -----LMGFSGGNVNWSTEEVAGNFAPSINDPISSLGYSRS--NSLLSKIYNWVHITEEKLLKHL 218
                 :|..|......:.......|...|:|.::   :|..  |:|:|
Zfish   178 YMLRGIMCESKATACPNPPSYIPRFFTQISDRMT---FSERVINTLVS----------------- 222

  Fly   219 IFRPSQLRIFKKFFNFSEQKFYNMREKYSVILVNNHISMGRV-------RSNVPNIIEVGGLHLT 276
            :..|...|:....|.....||.:.....:.||....:.:.|.       :..:||:|.:||:: .
Zfish   223 LLEPLMCRLMLGSFEEMTSKFLHRDVSITEILSTAAVWLMRYDFTLEFPKPLMPNMITIGGIN-C 286

  Fly   277 EPAEPCDSKLQKFMD-DAEHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVVWK--TELYN 338
            |...|...::::|:: ..|||::.||:|.  :|..:|::......|:.....|||:|:  .|:.|
Zfish   287 EVKNPLTKEVEEFVNGSGEHGIVVFSLGS--LVSSMPKEKADIFFKAFSMIPQRVLWRYTGEIPN 349

  Fly   339 MPNKSDNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNL 403
              |..:||.:::..||..:|.||..|.|||:||...:.|.:..|||::.||:|.||..|:..|..
Zfish   350 --NVPENVKLMKWLPQNDLLGHPKARAFITHGGTHGIYEGICHGVPMVMLPLFGDQADNVHRVAT 412

  Fly   404 RGMAEVLDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDA 468
            ||:..:|..:::|:|.|...:..::.|..|..|.:|:|....|||:.|||.||:|||:.:|:|.|
Zfish   413 RGVGVILSIHDITVETLLDALNSVINNSSYKQKMQKLSAIHNDRPIQPLDLAVFWTEFVMRHKGA 477

  Fly   469 SHMRLNTEDVPLYYEWDW 486
            .|:|      |..:|.:|
Zfish   478 DHLR------PAAHELNW 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	125/510 (25%)
ugt1b4	NP_001166239.2	UDPGT	35..529	CDD:278624	126/503 (25%)
ugt1b4	NP_001166239.2	egt	<273..512	CDD:223071	78/228 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584720
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830