DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B3 and ugt2a5

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001070111.2	Gene:	ugt2a5 / 767705	ZFINID:	ZDB-GENE-060929-796	Length:	532	Species:	Danio rerio

Alignment Length:	570	Identity:	146/570 - (25%)
Similarity:	250/570 - (43%)	Gaps:	110/570 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AVLFCLFLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITPVGMPTDIEG 73
            |:|.||.|   ...|...:..:|.:...:...||:  ||:.:|||.:.|:||::.....||
Zfish     5 ALLVCLLL---CGVDVGWSGRVLVMPGEYSHWHNM--RPVIEALVDKNHSVTVLVGSSSPT---- 60

  Fly    74 VRHIRVPKLNQRV----QEMIEGD----QILDFFGSKWIASLMVVSMLYNMSS------DI---- 120
            |.|.:..:....|    .|..|.|    .::..|.:...|......:::.:.|      |:
Zfish    61 VPHTQKERFEYHVFKVNMEKEEADAAMRDMIHLFTNDTAAKYEGEFVMWKVMSKFVEFGDVYFRG 125

  Fly   121 LSDKGVQKMLQNRNERFDLVMLEPSALEALYGVVEHYNATLMGFSG---------------GNVN 170
            |.|.|:.|.|::.|  :|::..:|                :|.||.               ....
Zfish   126 LFDVGLLKTLRDSN--YDVLFSDP----------------MMPFSDLMAQKLNIPQVISMRATFA 172

  Fly   171 WSTEEVAGNF-APSINDPISSLGYSRSNSLLSKIYNWVHITE--------EKLLKHLIFRPSQLR 226
            ::.|.:.|.. ||....|..:|              ..|:|:        |.:|.:::...:
Zfish   173 YAAERLCGQMPAPPSYVPAVAL--------------TDHLTDRMSFMERVENMLLYIVHSIA--- 220

  Fly   227 IFKKFFNFSEQKFYN--------MRE---KYSVILVNNHISMGRVRSNVPNIIEVGGLHLTEPAE 280
             |.....|:...:|:        |.|   |..:.|:..:......|...||...||||| .:||:
Zfish   221 -FPLVATFTFDGYYSEILGKPTTMCETMGKVDICLIRTYWDFEYPRPFPPNFKFVGGLH-CKPAK 283

  Fly   281 PCDSKLQKFMDDA-EHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVVWKTELYNMPNKSD 344
            |...:|::|:..: :|||:.||:|.  |::.|..:....:..:|.|..|:|||:.........:.
Zfish   284 PLSKELEEFVQSSGDHGVVVFSLGS--MIKNLTSERANTIAAALGQIPQKVVWRYSGKTPETLAP 346

  Fly   345 NVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEV 409
            |..:.:..||..:|.||.|:.|||:||...:.||:|.|||::|||:|.||..||.::..:|.|.|
Zfish   347 NTKIYDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFGDQPDNLLHIKTKGAAVV 411

  Fly   410 LDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASHMRLN 474
            ||.:.|..:.|...::.::.||.|.....::|:...|:||.|||.||:|.|:.:|||.|.|:|:.
Zfish   412 LDIHTMGSKDLVDALKAVVNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQ 476

  Fly   475 TEDVPLYYEWDW----GLLLGLRFGIVF---GSVIYLVYKLFQKTSARRR 517
            ..::. :|::..    ..||.:...|.|   .:..:|..:..:||...|:
Zfish   477 AHELS-WYQYHCLDVAAFLLSITALITFLWVKACCFLFRRCVRKTRPERK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	132/510 (26%)
ugt2a5	NP_001070111.2	UDPGT	21..519	CDD:278624	137/543 (25%)
ugt2a5	NP_001070111.2	egt	<249..485	CDD:223071	83/239 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585025
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.690