DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B3 and ugt5c2

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001038851.1	Gene:	ugt5c2 / 751669	ZFINID:	ZDB-GENE-060825-206	Length:	552	Species:	Danio rerio

Alignment Length:	509	Identity:	137/509 - (26%)
Similarity:	247/509 - (48%)	Gaps:	72/509 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SHNLVVRPLAKALVKRGHNVTLITPVGMPTDIEGVRH---IRVPKLN--------QRVQEMIEGD 93
            ||.:.:..|.|||..:||.|.:|.........|...:   |.:|...        ..|.:||:.:
Zfish    59 SHWVNMDILIKALHGQGHTVDVIRNANSWFIKENSTYYDTITIPNTKGWDEEFAADFVYKMIKYE 123

  Fly    94 Q-------ILDFFGSKWIASLMVVSMLYNMSSDILSDKGVQKMLQNRNERFDLVMLEPSALEALY 151
            :       |:..:.:.:.|......|:..:.::||..:.:.|||..:  ::||::.:|     ::
Zfish   124 KEKGSWLSIVRLYLNVFDAVKKTHEMVCQLITNILDSEEILKMLNEK--QYDLMLTDP-----VW 181

  Fly   152 G---VVEHYNATLMGFSGGNVNWSTEEVAGNF--APSIND--PISSLGYSRSNSLLSKIYNW-VH 208
            |   ::.|.....|.:   ||.|:|.. .|:|  |||...  ||:..|.:...|...::.|: .:
Zfish   182 GTGIILAHKLKLPMVY---NVRWTTTG-EGHFDIAPSPMSYIPITGSGNTDRMSFFQRLKNYFFY 242

  Fly   209 ITEEKLLKHLIFRPSQLRIFKKFFNFSE-----QKFYNMREKYSVILVNNHISMGRV-------R 261
            :..:..|.|              ||..:     .|::..|..:..:|....:.:.||       |
Zfish   243 LLLDLQLSH--------------FNVKQYQAICDKYFTSRVNFHELLQGADLWLMRVDFVFEFPR 293

  Fly   262 SNVPNIIEVGGLHLTEPAEPCDSKLQKFMDDA-EHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQ 325
            ..:||||.:||.. ..||:|....|:.||..: :||||..|:|.  ::..|||::...:..:..:
Zfish   294 PTMPNIIYIGGFQ-CPPAKPLPHDLEDFMQSSGDHGVIVMSLGS--LIGNLPENVTAEIAAAFAR 355

  Fly   326 FKQRVVWKTELYNMPNKSDNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPV 390
            ..|:|:|:.........|:|..:::..||:.:|.||.|::||::||...|:||:|.|||::|:|.
Zfish   356 LPQKVIWRYTGKKPSTLSNNTLMVDWMPQKDLLGHPKTKVFISHGGTNGVLEALYHGVPVIGIPF 420

  Fly   391 FFDQFINLRNVNLRGMAEVLDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTA 455
            ||||:.||..:..||.|::|...::....|.:.|::::..|.|.|...|:|...:|:|:.|||:|
Zfish   421 FFDQYDNLIRLQARGGAKLLSIADLGENTLHAAIQEVINEPSYRLNMHKLSHLHKDKPVKPLDSA 485

  Fly   456 VWWTEYALRNKDASHMRLNTEDVPLYYEWDWGLLLGLRFGIVFGSVIYLVYKLF 509
            ::|.|:.:|:|.|:|:|..:..:|.|......:::.|     |..|:.|.|.:|
Zfish   486 IFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVVVTL-----FAVVLILTYCIF 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	125/464 (27%)
ugt5c2	NP_001038851.1	UDPGT	49..551	CDD:278624	137/509 (27%)
ugt5c2	NP_001038851.1	egt	<288..528	CDD:223071	81/247 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585097
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.690