DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B3 and UGT8

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001121646.2	Gene:	UGT8 / 7368	HGNCID:	12555	Length:	541	Species:	Homo sapiens

Alignment Length:	534	Identity:	145/534 - (27%)
Similarity:	265/534 - (49%)	Gaps:	53/534 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 QAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITPVGMPTDIEGVRHI---RVPKL-NQRV 86
            :||.|:.:....|.||..:.:.||.||.:|||:...:...|  .||....|.   |.|.: |...
Human    19 KAAKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEG--RDIAPSNHYSLQRYPGIFNSTT 81

  Fly    87 QEMIEGDQILDFFGSKWIASLMVVSML--YNMSSDILSDKGVQKMLQN-RNERFDLVMLEPSALE 148
            .:.....::.:.|..: :.::.:..:|  |..:.|::  .|...::|. :.|:|||::::|:.:.
Human    82 SDAFLQSKMRNIFSGR-LTAIELFDILDHYTKNCDLM--VGNHALIQGLKKEKFDLLLVDPNDMC 143

  Fly   149 ALYGVVEHYNATLMG-----FSGGNVNWSTEEVAGNFAPSINDP-ISSLGYSRSNSLLSKIYN-W 206
            ..  |:.|    |:|     ||.|  .|...|| |..||....| .:||...|.| ||.::.| .
Human   144 GF--VIAH----LLGVKYAVFSTG--LWYPAEV-GAPAPLAYVPEFNSLLTDRMN-LLQRMKNTG 198

  Fly   207 VHITEEKLLKHLIFRPSQLRIFKKFFNFSEQKFYNMREKYSVILVNNHISMGRVRSNVPNIIEVG 271
            |::.....:..|:. |...||.:|:....|:..|::....|:.::...:::...|..:||::.||
Human   199 VYLISRLGVSFLVL-PKYERIMQKYNLLPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVG 262

  Fly   272 GLHLTEPAEPCDSKLQKFMDDA-EHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVVWKTE 335
            |: ||:||.|....||::::.| |||.:..|.|..  |::|.||:...|..:|.:..|:|:|:..
Human   263 GI-LTKPASPLPEDLQRWVNGANEHGFVLVSFGAG--VKYLSEDIANKLAGALGRLPQKVIWRFS 324

  Fly   336 LYNMPNKSDNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRN 400
            .....|..:|..:||..||..:|.|...:.|:::|||.|:.|.:|.|||::|:|:|.|.:..:..
Human   325 GPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETIYHGVPVVGIPLFGDHYDTMTR 389

  Fly   401 VNLRGMAEVLDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRN 465
            |..:||..:|:...:|.:.|...:.|::.||.|..:|:|:|:..:|:|..|::..::|.:|.:|:
Human   390 VQAKGMGILLEWKTVTEKELYEALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRH 454

  Fly   466 KDASHMRLNTEDVPL--YYEWDWGLLLGLRFGIVFGS---------VIYLVYKLFQKTSARRRPF 519
            ..|.|:|.....:..  |:      ||.:.|.::.|:         |...:|:..:...:|.:..
Human   455 NGAHHLRAAVHQISFCQYF------LLDIAFVLLLGAALLYFLLSWVTKFIYRKIKSLWSRNKHS 513

  Fly   520 QVTGTVSQHPSLLD 533
            .|.|  ..|..:|:
Human   514 TVNG--HYHNGILN 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	130/454 (29%)
UGT8	NP_001121646.2	Glycosyltransferase_GTB-type	21..502	CDD:415824	139/505 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150674
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740