DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B3 and UGT2B17

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001068.1	Gene:	UGT2B17 / 7367	HGNCID:	12547	Length:	530	Species:	Homo sapiens

Alignment Length:	552	Identity:	135/552 - (24%)
Similarity:	258/552 - (46%)	Gaps:	69/552 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WLAVLFCLFLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITPVGMPTDI 71
            |::|.  |.:|...|..|.....:| ::...: ||.:.::.:.:.||:|||.|.::|  ...:.:
Human     5 WMSVF--LLMQLSCYFSSGSCGKVL-VWPTEY-SHWINMKTILEELVQRGHEVIVLT--SSASIL 63

  Fly    72 EGVRHIRVPKLNQRVQEMIEGDQILDFF---GSKWIASL------MVVSML---------YN--M 116
            .........||......:.:.| :.|||   ..:|..|:      ...|.|         ||  :
Human    64 VNASKSSAIKLEVYPTSLTKND-LEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEYSDYNIKL 127

  Fly   117 SSDILSDKGVQKMLQNRNERFDLVMLEP-----SALEALYGVVEHYNATLMGFSGGNVNWSTEEV 176
            ..|.:.:|.:.:.||  ..:||:::.:.     ..|..|..:...|:   :.||   |.::.|:.
Human   128 CEDAVLNKKLMRKLQ--ESKFDVLLADAVNPCGELLAELLNIPFLYS---LRFS---VGYTVEKN 184

  Fly   177 AGNFA-PSINDPISSLGYSRSNSLLSKIYNWVHITEEKLLKHLIFRPSQLRIFKKFFNFSE---- 236
            .|.|. |....|:.....|.....:.:|.|.:::    |.....|:...|:.:.:|  :||
Human   185 GGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYM----LYFDFWFQAYDLKKWDQF--YSEVLGR 243

  Fly   237 -QKFYNMREKYSVILVNNHISMGRVRSNVPNIIEVGGLHLTEPAEPCDSKLQKFMDDA-EHGVIY 299
             ...:....|..:.|:..:......|..:||:..||||| .:||:|...::::|:..: |:|::.
Human   244 PTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLH-CKPAKPLPKEMEEFVQSSGENGIVV 307

  Fly   300 FSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVVWKTELYNMPNKSDNVYVIEQPPQRAVLAHPNTR 364
            ||:|.  |:..:.|:....:..:|.|..|:|:|:.:.........|..:.:..||..:|.||.|:
Human   308 FSLGS--MISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTK 370

  Fly   365 LFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEVLDANEMTLEILTSTIRKLLE 429
            .|||:||...:.||:|.|:|::|:|:|.||..|:.::..:|.|..:|...|:...|.:.::.::.
Human   371 AFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVIN 435

  Fly   430 NPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASHMRLNTEDVP--LYYEWDWGLLLGL 492
            :|.|.....|:|:...|:|:.|||.||:|.|:.:|:|.|.|:|:...::.  .|:..|   ::..
Human   436 DPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLD---VIAF 497

  Fly   493 RFGIVFGSVIYLVYK--LF-----QKTSARRR 517
            ....| .::|:::.|  ||     .||..:::
Human   498 LLACV-ATMIFMITKCCLFCFRKLAKTGKKKK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	122/490 (25%)
UGT2B17	NP_001068.1	UDPGT	24..518	CDD:278624	127/519 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150260
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.640