Protein Alignment Ugt303B3 and UGT2B15

DIOPT Version :10

• Sequence 1: NP_651152.1
• Gene: Ugt303B3 / 42774
• FlyBaseID: FBgn0039085
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001067.2
• Gene: UGT2B15 / 7366
• HGNCID: 12546
• Length: 530
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 138/560 - (24%)
• Similarity: 258/560 - (46%)
• Gaps: 92/560 - (16%)

  Fly     7 WLAVLFCLFLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITPVG----- 66
            |.:|.  |.:|...|..|.....:| ::...: ||.:.::.:.:.||:|||.||::|...
Human     5 WTSVF--LLIQLSCYFSSGSCGKVL-VWPTEY-SHWINMKTILEELVQRGHEVTVLTSSASTLVN 65

  Fly    67 -----------MPTDIEGVRHIRVPKLNQRVQEMIEGD--QILDFFGSKWIASL------MVVSM 112
                       .||.:              .:..:|..  :|||    :||..:      ...|.
Human    66 ASKSSAIKLEVYPTSL--------------TKNYLEDSLLKILD----RWIYGVSKNTFWSYFSQ 112

  Fly   113 L-------YNMSSDILSDKGVQK--MLQNRNERFDLVM---LEP--SALEALYGVVEHYNATLMG 163
            |       |:.|:.:..|..:.|  |::.:..:||:::   |.|  ..|..|:.:...|:   :.
Human   113 LQELCWEYYDYSNKLCKDAVLNKKLMMKLQESKFDVILADALNPCGELLAELFNIPFLYS---LR 174

  Fly   164 FSGGNVNWSTEEVAGNFA-PSINDPISSLGYSRSNSLLSKIYNWVHITEEKLLKHLIFRPSQLRI 227
            ||   |.::.|:..|.|. |....|:.....|.....:.:|.|.:|:    |.....|:...|:.
Human   175 FS---VGYTFEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIHM----LYFDFWFQIYDLKK 232

  Fly   228 FKKFFNFSE-----QKFYNMREKYSVILVNNHISMGRVRSNVPNIIEVGGLHLTEPAEPCDSKLQ 287
            :.:|  :||     ...:....|..:.|:..:......|..:||:..||||| .:||:|...:::
Human   233 WDQF--YSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLH-CKPAKPLPKEME 294

  Fly   288 KFMDDA-EHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVVWKTELYNMPNKSDNVYVIEQ 351
            :|:..: |:|::.||:|.  |:..:.|:....:..:|.|..|:|:|:.:.........|..:.:.
Human   295 EFVQSSGENGIVVFSLGS--MISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKW 357

  Fly   352 PPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEVLDANEMT 416
            .||..:|.||.|:.|||:||...:.||:|.|:|::|:|:|.||..|:.::..:|.|..:|...|:
Human   358 LPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMS 422

  Fly   417 LEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASHMRLNTEDVP-- 479
            ...|.:.::.::.:|.|.....|:|:...|:||.|||.||:|.|:.:|:|.|.|:|:...::.
Human   423 SRDLLNALKSVINDPVYKENVMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWI 487

  Fly   480 LYYEWDWGLLLGLRFGIVFGSVIYLVYKL----FQKTSAR 515
            .|:..|   ::......| .:||:::.|.    |:|.:.:
Human   488 QYHSLD---VIAFLLACV-ATVIFIITKFCLFCFRKLAKK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	GT1_Gtf-like	28..458	CDD:340817	117/474 (25%)
UGT2B15	NP_001067.2	UDPGT	24..518	CDD:278624	130/532 (24%)