Protein Alignment Ugt303B3 and UGT2B7

DIOPT Version :10

• Sequence 1: NP_651152.1
• Gene: Ugt303B3 / 42774
• FlyBaseID: FBgn0039085
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001065.2
• Gene: UGT2B7 / 7364
• HGNCID: 12554
• Length: 529
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 145/560 - (25%)
• Similarity: 258/560 - (46%)
• Gaps: 113/560 - (20%)

  Fly     7 WLAVLFCLFLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTL---------- 61
            |.:|:  |.:|......|.....:| :::..: ||.:.::.:...|::|||.||:
Human     5 WTSVI--LLIQLSFCFSSGNCGKVL-VWAAEY-SHWMNIKTILDELIQRGHEVTVLASSASILFD 65

  Fly    62 ----------ITPVGM-PTDIEG--VRHIR----VPK-----LNQRVQEMIEGDQILDFFGSKWI 104
                      |.|..: .|::|.  ::.|:    :||     ...:|||      |:..||
Human    66 PNNSSALKIEIYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQE------IMSIFG---- 120

  Fly   105 ASLMVVSMLYNMSSDILSDKGVQKMLQNRNERFDLVMLE-----PSALEALYGVVEHYNATLMGF 164
                  .:......|::|:|...|.:|  ..|||::..:     ...|..|:.:...|:   :.|
Human   121 ------DITRKFCKDVVSNKKFMKKVQ--ESRFDVIFADAIFPCSELLAELFNIPFVYS---LSF 174

  Fly   165 SGGNVNWSTEEVAGNFA-PSINDPISSLGYSRSNSLLSKIYN---------WVHITE----EKLL 215
            |.|   ::.|:.:|.|. |....|:.....:...:.:.::.|         |..|.:    ::..
Human   175 SPG---YTFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFY 236

  Fly   216 KHLIFRPSQLRIFKKFFNFSEQKFYNMREKYSVILVNNHISMGRVRSNVPNIIEVGGLHLTEPAE 280
            ..::.||:.|         ||     ...|..|.|:.|..:.......:||:..||||| .:||:
Human   237 SEVLGRPTTL---------SE-----TMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLH-CKPAK 286

  Fly   281 PCDSKLQKFMDDA-EHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVVWKTELYNMPNKSD 344
            |...:::.|:..: |:||:.||:|.  ||..:.|:....:..:|.|..|:|:|:.:    .||.|
Human   287 PLPKEMEDFVQSSGENGVVVFSLGS--MVSNMTEERANVIASALAQIPQKVLWRFD----GNKPD 345

  Fly   345 ----NVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRG 405
                |..:.:..||..:|.||.||.|||:||...:.||:|.|:|::|:|:|.||..|:.::..||
Human   346 TLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARG 410

  Fly   406 MAEVLDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASH 470
            .|..:|.|.|:...|.:.:::::.:|.|.....|:|:...|:|:.|||.||:|.|:.:|:|.|.|
Human   411 AAVRVDFNTMSSTDLLNALKRVINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKH 475

  Fly   471 MRLNTEDVP--LYYEWD-WGLLLGLRFGIVFGSVIYLVYK 507
            :|:...|:.  .|:..| .|.||     :...:||::|.|
Human   476 LRVAAHDLTWFQYHSLDVIGFLL-----VCVATVIFIVTK 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	GT1_Gtf-like	28..458	CDD:340817	123/485 (25%)
UGT2B7	NP_001065.2	UDPGT	24..525	CDD:278624	140/539 (26%)