Protein Alignment Ugt303B3 and UGT2B4

DIOPT Version :9

• Sequence 1: NP_651152.1
• Gene: Ugt303B3 / 42774
• FlyBaseID: FBgn0039085
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_066962.2
• Gene: UGT2B4 / 7363
• HGNCID: 12553
• Length: 528
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 148/566 - (26%)
• Similarity: 262/566 - (46%)
• Gaps: 103/566 - (18%)

  Fly     7 WLAVLFCLFLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLIT-------- 63
            |.:.|  |.:|...|..|.....:| ::...| ||.:.::.:...||:|||.||::.
Human     5 WTSAL--LLIQLSCYFSSGSCGKVL-VWPTEF-SHWMNIKTILDELVQRGHEVTVLASSASISFD 65

  Fly    64 ------------PVGM-PTDIEGVRHIRVPKLNQRVQEMIEGDQILDFFGS----KWIASLMVVS 111
                        ||.: .|:.|.:    :.:|.:|..|:.: |....:|..    .|..:    .
Human    66 PNSPSTLKFEVYPVSLTKTEFEDI----IKQLVKRWAELPK-DTFWSYFSQVQEIMWTFN----D 121

  Fly   112 MLYNMSSDILSDKGVQKMLQNRNERFDLVMLEP-----SALEALYGVVEHYNATLMGFSGGNVNW 171
            :|.....||:|:|.:.|.||  ..|||:|:.:.     ..|..|..:...|:   :.||.|   :
Human   122 ILRKFCKDIVSNKKLMKKLQ--ESRFDVVLADAVFPFGELLAELLKIPFVYS---LRFSPG---Y 178

  Fly   172 STEEVAGN--FAPSINDPISSLGYSRSNSLLSKIYNWVHITEEKLLKHLIFRPSQLRIFKKFFNF 234
            :.|:.:|.  |.||. .|:.....|...:.:.::.|.:::.                .|:.:|..
Human   179 AIEKHSGGLLFPPSY-VPVVMSELSDQMTFIERVKNMIYVL----------------YFEFWFQI 226

  Fly   235 SEQK----FYN-----------MREKYSVILVNNHISMGRVRSNVPNIIEVGGLHLTEPAEPCDS 284
            .:.|    ||:           ...|..:.|:.|:.........:||:..||||| .:||:|...
Human   227 FDMKKWDQFYSEVLGRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLH-CKPAKPLPK 290

  Fly   285 KLQKFMDDA-EHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVVWKTELYNMPNKSD---- 344
            ::::|:..: |:||:.||:|.  ||....|:....:..:|.:..|:|:|:.:    .||.|
Human   291 EMEEFVQSSGENGVVVFSLGS--MVSNTSEERANVIASALAKIPQKVLWRFD----GNKPDTLGL 349

  Fly   345 NVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEV 409
            |..:.:..||..:|.||.||.|||:||...:.||:|.|:|::|:|:|.||..|:.::..:|.|..
Human   350 NTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVS 414

  Fly   410 LDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASHMRLN 474
            ||.:.|:...|.:.::.::.:|.|...|.|:|:...|:|:.|||.||:|.|:.:|:|.|.|:|:.
Human   415 LDFHTMSSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVA 479

  Fly   475 TEDVP--LYYEWD-WGLLLGLRFGIVF--GSVIYLVYKLFQKTSAR 515
            ..|:.  .|:..| .|.||.....::|  ...::.|:| |.:|..:
Human   480 AHDLTWFQYHSLDVTGFLLACVATVIFIITKCLFCVWK-FVRTGKK 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	133/510 (26%)
UGT2B4	NP_066962.2	egt	8..512	CDD:223071	143/548 (26%)
		UDPGT	24..524	CDD:278624	142/543 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150442
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.640