DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B3 and ugt5a1

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001032497.2	Gene:	ugt5a1 / 641479	ZFINID:	ZDB-GENE-051120-60	Length:	525	Species:	Danio rerio

Alignment Length:	523	Identity:	138/523 - (26%)
Similarity:	250/523 - (47%)	Gaps:	77/523 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SHNLVVRPLAKALVKRGHNVTLITPV---------------------GMPTDIEGVRHIRVPKLN 83
            ||.:.::.|.:.|.::|||||::.|.                     |...:..|:...|:.::.
Zfish    32 SHWVNMKVLIEELHRKGHNVTVVRPSNSWYIKEESPFYSSITIPNTGGFDEEFSGLLINRLLEIK 96

  Fly    84 Q-------RVQEMIEGDQILDFFGSKWIASLMVVSMLYNMSSDILSDKGVQKMLQNRNERFDLVM 141
            :       ||:  :|.:.::.|       ..|...|| .|...:|.|:.|...:|  :.:||:|:
Zfish    97 RGGYFVLNRVR--LEFEIMMKF-------KTMHEDML-QMMDRMLEDEKVMNSIQ--DAKFDVVL 149

  Fly   142 LEPSALEALYG---VVEHYNATLMGFSGGNVNWSTEEVAGNFA----PSINDPISSLGYSRSNSL 199
            .:|    |:.|   :...:|..|:    .||.| |.:..|:||    |....|:..:..:...|.
Zfish   150 ADP----AVGGGPILAYKFNIPLV----FNVRW-TIQGEGHFAIAPSPLSYIPVPGVELTDKMSF 205

  Fly   200 LSKIYNWVHITEEKLLKHLIFRPSQLRIFKKFFNFSEQKFYNMREKYSVILVNNHISMGRVRSNV 264
            |.::.|.:.....::...::..|.......|.|. ....::::.:...:.|:.|..:....|..:
Zfish   206 LQRVKNVLIYLISQIQMQIMVEPIYAPFCHKHFG-PNVTYFSLFQDADIWLMRNDFTFEFPRPTM 269

  Fly   265 PNIIEVGGLHLTEPAEPCDSKLQKFMDDA-EHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQ 328
            |||:.:.|.. .:||:|..:.|:||::.: |||||..|:|  .::..||:||..::..:..:..|
Zfish   270 PNIVYMSGFQ-CKPAKPLPNDLEKFVESSGEHGVIVMSLG--TLIAQLPQDMTDDIAAAFAELPQ 331

  Fly   329 RVVWKTELYNMPNK---SDNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPV 390
            :|:|:   |..|..   .:|..::|..||..:|.||..::|:.:||...:.||:|.||||||||:
Zfish   332 KVIWR---YTGPRPVTLGNNTLLVEWLPQNDLLGHPQIKVFVAHGGTNGIQEAIYHGVPILGLPL 393

  Fly   391 FFDQFINLRNVNLRGMAEVLDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTA 455
            .|||..||..:..:|.|:::|...:...:....::::|.||.|....:::|:...|:|:.|||.|
Zfish   394 VFDQPDNLFRMEAKGTAKIVDIATLDKTVFLEALKEVLYNPSYRENMQRLSKLHHDQPLKPLDRA 458

  Fly   456 VWWTEYALRNKDASHMRLNTEDVPL----YYEWDWGLLL---GLRFGIVFGSVI-YLVYKLFQKT 512
            ::|.|:.:|||.|.|:|  |:...:    |:..|..|.|   |..|.::.|..| |....:|:|.
Zfish   459 MFWIEFVMRNKGAPHLR--TQSFRMSWIEYHSIDVILTLMVTGFVFALMIGYTIKYFCLCVFRKK 521

  Fly   513 SAR 515
            ..|
Zfish   522 VKR 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	120/464 (26%)
ugt5a1	NP_001032497.2	UDPGT	22..525	CDD:278624	138/523 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584442
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.690