DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B3 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001365304.1	Gene:	Ugt1a8 / 613123	MGIID:	3576090	Length:	530	Species:	Mus musculus

Alignment Length:	528	Identity:	131/528 - (24%)
Similarity:	252/528 - (47%)	Gaps:	60/528 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LAVLFCLFLQKDLYQDSVQAANILGI--FSYHFSSHNLVVRPLAKALVKRGHNVTLITP-----V 65
            |.:..||.|...|    .||..:|.:  ...|:.|..::|..|:    .|||.|.::.|     :
Mouse    10 LPLRVCLLLAFGL----AQAGRLLVVPMDGSHWFSMKMIVEKLS----HRGHEVVVVIPEVSWHL 66

  Fly    66 GMPTDIEGVRHIRVPKLNQRVQEMIEGDQILDFFGSK-W------IASLMVVS------MLYNMS 117
            |...:..    ::...::..::::   ....:||..| |      :.||:..|      :|::..
Mouse    67 GKSQNFT----VKTYSVSYTLEDL---SHHFNFFAHKQWENREVGMFSLLKHSGKGFFQVLFSHC 124

  Fly   118 SDILSDKGVQKMLQNRNERFDLVMLEPSALEALYGVVEHYNATLMGFSGGNVNWSTEEVAGNFAP 182
            ..:.:||.:.:.|:.|:  ||.|.|:|..:..| .:.::::...:.||||......:|.|...:|
Mouse   125 RSLFNDKKLVEYLKQRS--FDAVFLDPFDVCGL-TIAKYFSLPSVVFSGGIFCHYLDEGAQCPSP 186

  Fly   183 SINDPISSLGYSRSNSLLSKIYNWVHITEEKLLKHLIFRPSQLRIFKKFFNFSEQKFYNMREKYS 247
            ....|.....::.:.:...:::|:....:|:......|: :.:.|..:..    |....|.:.:|
Mouse   187 PSYVPRILSKFADTMTFKERVWNYFSYMKERAFCPYFFK-TAIEIASEVL----QTPVTMTDLFS 246

  Fly   248 VILVNNHISMGRV-------RSNVPNIIEVGGLHLTEPAEPCDSKLQKFMD-DAEHGVIYFSMGQ 304
            .:    .|.|.|.       |..:||::.:||:: ..|.:|...:.:.::: ..|||::.||:|.
Mouse   247 SV----SIWMFRTDFVLEFPRPVMPNMVYIGGIN-CHPGKPLSKEFEAYVNASGEHGIVVFSLGS 306

  Fly   305 EIMVQFLPEDMQQNLMKSLDQFKQRVVWKTELYNMPNKSDNVYVIEQPPQRAVLAHPNTRLFITN 369
              ||..:||.....:.::|.:..|.|:|:.......|.:.|..:::..||..:|.||.||.|||:
Mouse   307 --MVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITH 369

  Fly   370 GGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEVLDANEMTLEILTSTIRKLLENPRYA 434
            .|...:.|.:.:|||::.:|:|.||..|.:.:..||....|:..|||.:.|.:.::.::.|..|.
Mouse   370 SGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYK 434

  Fly   435 LKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASHMRLNTEDVPLYYEWDWGLLLGLRFGIVFG 499
            ....::|...:|||:.|||.||:|.||.:|:|.|.|:|....|: .:|::....::|....||.
Mouse   435 ENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDL-TWYQYHSLDVIGFLLAIVL- 497

  Fly   500 SVIYLVYK 507
            :|:::|:|
Mouse   498 TVVFIVFK 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	119/485 (25%)
Ugt1a8	NP_001365304.1	UDPGT	26..521	CDD:278624	124/508 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840351
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.640