Protein Alignment Ugt303B3 and UGT2A2

DIOPT Version :10

• Sequence 1: NP_651152.1
• Gene: Ugt303B3 / 42774
• FlyBaseID: FBgn0039085
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001099147.2
• Gene: UGT2A2 / 574537
• HGNCID: 28183
• Length: 536
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 134/534 - (25%)
• Similarity: 225/534 - (42%)
• Gaps: 126/534 - (23%)

  Fly    40 SHNLVVRPLAKALVKRGHNVTLI-------------TPVGMPTDIEGVRHIRVPKLNQRVQEMIE 91
            ||.|.::.:.:.|::|.||||::             :||....       |.|......:..:||
Human    40 SHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEV-------IPVSYKKSNIDSLIE 97

  Fly    92 GDQILDFFGSKWI---ASLMVVSMLYNMSSDILSD---------KGVQK----MLQNRNERFDLV 140
            ...:|      ||   .:.:.:...|.....:|..         .||.|    |.:.:...||::
Human    98 HMIML------WIDHRPTPLTIWAFYKELGKLLDTFFQINIQLCDGVLKNPKLMARLQKGGFDVL 156

  Fly   141 MLEP-------------------------SALEALYG----VVEHYNATL------MGFSGGNVN 170
            :.:|                         |.:|...|    .|.:..|.|      |.|.
Human   157 VADPVTICGDLVALKLGIPFMYTLRFSPASTVERHCGKIPAPVSYVPAALSELTDQMTFG----- 216

  Fly   171 WSTEEVAGNFAPSINDPISSLGYSRSNSLLSKIYNWVHITEEKLLKHLIFRPSQLRIFKKFFNFS 235
               |.:....:.|:.|.|....:...||..|||               :.||:.|
Human   217 ---ERIKNTISYSLQDYIFQSYWGEWNSYYSKI---------------LGRPTTL---------- 253

  Fly   236 EQKFYNMREKYSVILVNNHISMGRVRSNVPNIIEVGGLHLTEPAEPCDSKLQKFMDDA-EHGVIY 299
                .....|..:.|:..:......|..:||...||||| .:||:|...::::|:..: ::||:.
Human   254 ----CETMGKAEIWLIRTYWDFEFPRPYLPNFEFVGGLH-CKPAKPLPKEMEEFIQSSGKNGVVV 313

  Fly   300 FSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVVWKTELYNMPNKSDNVYVIEQPPQRAVLAHPNTR 364
            ||:|.  ||:.|.|:....:..:|.|..|:|:|:.:........:|..:.:..||..:|.||.|:
Human   314 FSLGS--MVKNLTEEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDLLGHPKTK 376

  Fly   365 LFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEVLDANEMTLEILTSTIRKLLE 429
            .|||:||...:.||:|.|||::|:|:|.||..|:.::..:|.|..::.|.||...|.|.:|.::.
Human   377 AFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVIN 441

  Fly   430 NPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASHMRLNTEDVP--LYYEWD-WGLLLG 491
            .|.|...|.::|:...|:|:.|||.||:|.|:.:|:|.|.|:|:...|:.  .|:..| .|.||
Human   442 EPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLL- 505

  Fly   492 LRFGIVFGSVIYLV 505
                :...:.|:||
Human   506 ----VCVTTAIFLV 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	GT1_Gtf-like	28..458	CDD:340817	118/482 (24%)
UGT2A2	NP_001099147.2	UDPGT	30..524	CDD:278624	134/534 (25%)