DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B3 and ugt2a2

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001018306.2	Gene:	ugt2a2 / 553952	ZFINID:	ZDB-GENE-080721-21	Length:	534	Species:	Danio rerio

Alignment Length:	554	Identity:	144/554 - (25%)
Similarity:	245/554 - (44%)	Gaps:	105/554 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ILGIFSYHFSSHNLV----------VRPLAKALVKRGHNVTLITPVGMPT--------------- 69
            ::.|||:..:.:.||          :|.:...|:.|.|.||::.....||
Zfish    13 LIFIFSFTHAGNVLVLPGEYSHWQNMRNVVDELLNRNHTVTVLVCSASPTINFTQQERFQYLVFE 77

  Fly    70 ------DIEGVR----HI--RVPKLNQRVQEMIEGDQILDFFGS-KWIASLMVVSMLYNMSSDIL 121
                  :::|..    ||  :.|..| |:|..:   ||::..|. :.:...|..|||.|   |.|
Zfish    78 VPLSAQELDGASEELIHIWTQHPSPN-RLQTAL---QIIELLGRVRVMHRAMCDSMLRN---DAL 135

  Fly   122 SDKGVQKMLQNRNERFDLVMLEPSALEALYGVVEHYNATLMG--------FSGGNVNWSTEEVAG 178
                   :.|....:||::..:|..:.|      ...|.::|        .|.|   :..|.:.|
Zfish   136 -------IAQLSALKFDVLFNDPMFMCA------DLLAEMLGLPLVLSVRISPG---FCLERMCG 184

  Fly   179 NF-APSINDPISSLGYSRSNSLLSKIYNWVHITEEKLLKHLIFRPSQLRIFKKFFNFSEQKFY-- 240
            .. ||....||:....:.....:.::.|        ::.:::|..|    |......|...:|
Zfish   185 QMPAPPSFVPITQTVLTDRMCFMERVQN--------MIANIVFSVS----FYIVAWISLDSYYTD 237

  Fly   241 ------NMRE---KYSVILVNNHISMGRVRSNVPNIIEVGGLHLTEPAEPCDSKLQKFMDDA-EH 295
                  .|.|   |..:.|:..:......|...||...||||| .:||:|...::::|:..: :|
Zfish   238 VLGKPTTMCETMGKADIWLIRTYWDFEYPRPFPPNFKFVGGLH-CKPAKPLSKEMEEFVQSSGDH 301

  Fly   296 GVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVVWKTELYNMPNKSDNVYVIEQPPQRAVLAH 360
            ||:.||:|.  |::.|..:....:..:|.|..|:|||:.........:.|..:.:..||..:|.|
Zfish   302 GVVVFSLGS--MIKNLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGH 364

  Fly   361 PNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEVLDANEMTLEILTSTIR 425
            |.|:.|||:||...:.||:|.|||::|||:|.||..||.::..:|.|.|||.|.:..:.|...::
Zfish   365 PKTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDALK 429

  Fly   426 KLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASHMRLNTEDVPLYYEWDW---- 486
            .:|.||.|.....::|:...|:||.|||.||:|.|:.:|||.|.|:|:...::. :|::..
Zfish   430 TVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELS-WYQYHCLDVA 493

  Fly   487 GLLLGLRFGIVF---GSVIYLVYKLFQKTSARRR 517
            ..||.:...|.|   .:..:|..:..:||...|:
Zfish   494 AFLLSIAALITFLWVKACCFLFRRCVRKTRPERK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	130/494 (26%)
ugt2a2	NP_001018306.2	UDPGT	23..521	CDD:278624	138/536 (26%)
ugt2a2	NP_001018306.2	egt	<256..487	CDD:223071	82/234 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.860