DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B3 and UGT1A1

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_000454.1	Gene:	UGT1A1 / 54658	HGNCID:	12530	Length:	533	Species:	Homo sapiens

Alignment Length:	491	Identity:	117/491 - (23%)
Similarity:	227/491 - (46%)	Gaps:	43/491 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SHNLVVRPLAKALVKRGHNVTLITPVGMPTDIEGVRHIR-----------VPKLNQRVQE----- 88
            ||.|.:....:.|.:|||.:.::.|       :...:||           ||...:.|:|
Human    38 SHWLSMLGAIQQLQQRGHEIVVLAP-------DASLYIRDGAFYTLKTYPVPFQREDVKESFVSL 95

  Fly    89 ---MIEGDQILDFFGSKWIASLMVVSMLYNMSSDILSDKGVQKMLQNRNERFDLVMLEPSALEAL 150
               :.|.|..|......:.......:||.:..|.:|.:|.:...|...:  ||:::.:| .|...
Human    96 GHNVFENDSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKELMASLAESS--FDVMLTDP-FLPCS 157

  Fly   151 YGVVEHYNATLMGFSGG---NVNWSTEEVAGNFAPSINDPISSLGYSRSNSLLSKIYNWVHITEE 212
            ..|.::.:...:.|...   ::.:...:....|: .:..|:||  :|...:.|.::.|.:....:
Human   158 PIVAQYLSLPTVFFLHALPCSLEFEATQCPNPFS-YVPRPLSS--HSDHMTFLQRVKNMLIAFSQ 219

  Fly   213 KLLKHLIFRPSQLRIFKKFFNFSEQKFYNMREKYSVILVNNHISMGRVRSNVPNIIEVGGLHLTE 277
            ..|..:::.| ...:..:|.. .|....::....||.|..:.......|..:||::.|||::...
Human   220 NFLCDVVYSP-YATLASEFLQ-REVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLH 282

  Fly   278 PAEPCDSKLQKFMD-DAEHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVVWKTELYNMPN 341
             ..|...:.:.::: ..|||::.||:|.  ||..:||.....:..:|.:..|.|:|:.......|
Human   283 -QNPLSQEFEAYINASGEHGIVVFSLGS--MVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSN 344

  Fly   342 KSDNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGM 406
            .::|..:::..||..:|.||.||.|||:.|...|.|::.:|||::.:|:|.||..|.:.:..:|.
Human   345 LANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGA 409

  Fly   407 AEVLDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASHM 471
            ...|:..|||.|.|.:.::.::.:..|.....::|...:|||:.|||.||:|.|:.:|:|.|.|:
Human   410 GVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHL 474

  Fly   472 RLNTEDVPLYYEWDWGLLLGLRFGIVFGSVIYLVYK 507
            |....|: .:|::....::|....:|. :|.::.:|
Human   475 RPAAHDL-TWYQYHSLDVIGFLLAVVL-TVAFITFK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	107/448 (24%)
UGT1A1	NP_000454.1	UDPGT	28..524	CDD:278624	117/491 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150314
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.640