Protein Alignment Ugt303B3 and UGT1A4

DIOPT Version :10

• Sequence 1: NP_651152.1
• Gene: Ugt303B3 / 42774
• FlyBaseID: FBgn0039085
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_009051.1
• Gene: UGT1A4 / 54657
• HGNCID: 12536
• Length: 534
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 126/503 - (25%)
• Similarity: 232/503 - (46%)
• Gaps: 73/503 - (14%)

  Fly    43 LVVRPLAKALVKRGHNVTLITP-VGMPTDIEGVRHIR-----------VP---KLNQRV-----Q 87
            |.:|...:.|..|||...::|| |.|        ||:           ||   |...||     |
Human    42 LSMREALRELHARGHQAVVLTPEVNM--------HIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQ 98

  Fly    88 EMIEGDQILDFFGSKWIASLMVVSM-LYNMSSDILSDKGVQKMLQNRNERFDLVMLEP----SAL 147
            ...|.:.:|..: |:.:|.:..||: |:....::|.::.:.:.|...:  ||:|:.:|    .|:
Human    99 GFFETEHLLKRY-SRSMAIMNNVSLALHRCCVELLHNEALIRHLNATS--FDVVLTDPVNLCGAV 160

  Fly   148 EALYGVVE-----HYNATLMGFSGGNVNWSTEEVAGNFAPSINDPISSLGYSRSN--SLLSKIYN 205
            .|.|..:.     .|....:.|.|..            .|:.:..|..|..:.|:  :.|.::.|
Human   161 LAKYLSIPAVFFWRYIPCDLDFKGTQ------------CPNPSSYIPKLLTTNSDHMTFLQRVKN 213

  Fly   206 WVHITEEKLLKHLIFRP-----SQLRIFKKFFNFSEQKFYNMREKYSVILVNNHISMGRVRSNVP 265
            .::......:.|....|     |:|  |::     |....::....||.|......|...|..:|
Human   214 MLYPLALSYICHTFSAPYASLASEL--FQR-----EVSVVDLVSYASVWLFRGDFVMDYPRPIMP 271

  Fly   266 NIIEVGGLHLTEPAEPCDSKLQKFMD-DAEHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQR 329
            |::.:||::... .:|...:.:.::: ..|||::.||:|.  ||..:||.....:..:|.:..|.
Human   272 NMVFIGGINCAN-GKPLSQEFEAYINASGEHGIVVFSLGS--MVSEIPEKKAMAIADALGKIPQT 333

  Fly   330 VVWKTELYNMPNKSDNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQ 394
            |:|:.......|.::|..:::..||..:|.||.||.|||:.|...|.|::.:|||::.:|:|.||
Human   334 VLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQ 398

  Fly   395 FINLRNVNLRGMAEVLDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWT 459
            ..|.:.:..:|....|:..|||.|.|.:.::.::.:..|.....::|...:|||:.|||.||:|.
Human   399 MDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWV 463

  Fly   460 EYALRNKDASHMRLNTEDVPLYYEWDWGLLLGLRFGIVFGSVIYLVYK 507
            |:.:|:|.|.|:|....|: .:|::....::|....:|. :|.::.:|
Human   464 EFVMRHKGAPHLRPAAHDL-TWYQYHSLDVIGFLLAVVL-TVAFITFK 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	GT1_Gtf-like	28..458	CDD:340817	113/452 (25%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	126/503 (25%)