Protein Alignment Ugt303B3 and UGT1A6

DIOPT Version :10

• Sequence 1: NP_651152.1
• Gene: Ugt303B3 / 42774
• FlyBaseID: FBgn0039085
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001063.2
• Gene: UGT1A6 / 54578
• HGNCID: 12538
• Length: 532
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 119/512 - (23%)
• Similarity: 228/512 - (44%)
• Gaps: 85/512 - (16%)

  Fly    40 SHNLVVRPLAKALVKRGHNVTLITP----------------VGMPTDIEGVRHIRVPKLNQRVQE 88
            ||.|.::.:.:.|..|||.:.::.|                ..:|.|.|        :|..|.|.
Human    37 SHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRKIYPVPYDQE--------ELKNRYQS 93

  Fly    89 MIEGDQILDFFGSKWIA--------------SLMVVSMLYNMSSDILSDKGVQKMLQNRNERFDL 139
                      ||:...|              :::|:.:.:.....:|.|:......  :..:||.
Human    94 ----------FGNNHFAERSFLTAPQTEYRNNMIVIGLYFINCQSLLQDRDTLNFF--KESKFDA 146

  Fly   140 VMLEPS-----ALEALYGVVEHYNATLMGFSGGNVNWSTEEVAGNFAPSINDPISSL-----GYS 194
            :..:|:     .|....|:...|  ...||.     .|.|.   .|:.| .||:|.:     .:|
Human   147 LFTDPALPCGVILAEYLGLPSVY--LFRGFP-----CSLEH---TFSRS-PDPVSYIPRCYTKFS 200

  Fly   195 RSNSLLSKIYNW-VHITEEKLLKHLIFRPSQL--RIFKKFFNFSEQKFYNMREKYSVILVNNHIS 256
            ...:...::.|: |::.|..|...|..:..:|  .:.|:     :.....:.:|.||.|:.....
Human   201 DHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKR-----DVDIITLYQKVSVWLLRYDFV 260

  Fly   257 MGRVRSNVPNIIEVGGLHLTEPAEPCDSKLQKFMD-DAEHGVIYFSMGQEIMVQFLPEDMQQNLM 320
            :...|..:||::.:||:: .:..:....:.:.::: ..|||::.||:|.  ||..:||.....:.
Human   261 LEYPRPVMPNMVFIGGIN-CKKRKDLSQEFEAYINASGEHGIVVFSLGS--MVSEIPEKKAMAIA 322

  Fly   321 KSLDQFKQRVVWKTELYNMPNKSDNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPI 385
            .:|.:..|.|:|:.......|.::|..:::..||..:|.||.||.|||:.|...|.|::.:|||:
Human   323 DALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPM 387

  Fly   386 LGLPVFFDQFINLRNVNLRGMAEVLDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMS 450
            :.:|:|.||..|.:.:..:|....|:..|||.|.|.:.::.::.:..|.....::|...:|||:.
Human   388 VMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVE 452

  Fly   451 PLDTAVWWTEYALRNKDASHMRLNTEDVPLYYEWDWGLLLGLRFGIVFGSVIYLVYK 507
            |||.||:|.|:.:|:|.|.|:|....|: .:|::....::|....:|. :|.::.:|
Human   453 PLDLAVFWVEFVMRHKGAPHLRPAAHDL-TWYQYHSLDVIGFLLAVVL-TVAFITFK 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	GT1_Gtf-like	28..458	CDD:340817	106/461 (23%)
UGT1A6	NP_001063.2	UDPGT	27..523	CDD:278624	119/512 (23%)