Protein Alignment Ugt303B3 and UGT1A7

DIOPT Version :10

• Sequence 1: NP_651152.1
• Gene: Ugt303B3 / 42774
• FlyBaseID: FBgn0039085
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_061950.2
• Gene: UGT1A7 / 54577
• HGNCID: 12539
• Length: 530
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 125/501 - (24%)
• Similarity: 235/501 - (46%)
• Gaps: 64/501 - (12%)

  Fly    40 SHNLVVRPLAKALVKRGHNVTLITP-----VGMPTDIEGVRHIRVPKLNQRVQEMIEGDQILDFF 99
            ||...::.:.:.|:.|||.|.::.|     :|...:..    ::....:..:::  :..:.:.|.
Human    36 SHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGRSLNCT----VKTYSTSYTLED--QDREFMVFA 94

  Fly   100 GSKWIASLMVVSMLYNMSSDILSDKGVQKMLQNRNER----------FDLVMLEPSALEALYGVV 154
            .::|.|.|.....|...||:.:.|..........|:|          ||.|.|:|.....|. |.
Human    95 DARWTAPLRSAFSLLTSSSNGIFDLFFSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLI-VA 158

  Fly   155 EHYNATLMGFSGGNVNWSTEEVAGNFAPSINDPISSLGYSRSNSLLSKIYNWVHITEEKLLKHLI 219
            ::::...:.|:.|......||.|...||....|...||:|.:.:...:::|.:...||.|
Human   159 KYFSLPSVVFARGIFCHYLEEGAQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHL----- 218

  Fly   220 FRPSQLRIFKKFFNFSEQKFYNMREKYSVIL--------VNNHISMGRVRSN---------VPNI 267
                    |..:|      |.|:.|..|.||        :.:|.|:..:|::         :||:
Human   219 --------FCPYF------FKNVLEIASEILQTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNM 269

  Fly   268 IEVGGLHLTEPAEPCDSKLQKFMD-DAEHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVV 331
            |.:||::..: .:|...:.:.::: ..|||::.||:|.  ||..:||.....:..:|.:..|.|:
Human   270 IFIGGINCHQ-GKPVPMEFEAYINASGEHGIVVFSLGS--MVSEIPEKKAMAIADALGKIPQTVL 331

  Fly   332 WKTELYNMPNKSDNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFI 396
            |:.......|.::|..:::..||..:|.||.||.|||:.|...|.|::.:|||::.:|:|.||..
Human   332 WRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMD 396

  Fly   397 NLRNVNLRGMAEVLDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEY 461
            |.:.:..:|....|:..|||.|.|.:.::.::.:..|.....::|...:|||:.|||.||:|.|:
Human   397 NAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEF 461

  Fly   462 ALRNKDASHMRLNTEDVPLYYEWDWGLLLGLRFGIVFGSVIYLVYK 507
            .:|:|.|.|:|....|: .:|::....::|....:|. :|.::.:|
Human   462 VMRHKGAPHLRPAAHDL-TWYQYHSLDVIGFLLAVVL-TVAFITFK 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	GT1_Gtf-like	28..458	CDD:340817	112/450 (25%)
UGT1A7	NP_061950.2	UDPGT	26..521	CDD:278624	125/501 (25%)