DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B3 and Ugt37D1

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001285989.1	Gene:	Ugt37D1 / 53511	FlyBaseID:	FBgn0040260	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	578	Identity:	159/578 - (27%)
Similarity:	261/578 - (45%)	Gaps:	130/578 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LAVLFCLFLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITPVGMPTDIE 72
            |..|....|.........:.|||||:|:.|..||.:|...:.|.|.::|||||:::.|......:
  Fly    13 LGGLLVALLALQTMPQGTEGANILGVFTSHSPSHFIVHMSIMKTLAEKGHNVTVVSSVPPKVTHK 77

  Fly    73 GVRHIRVPK-------LNQRVQEMIE-----GDQILDFFGSKWIASLMVVSMLYNMSSDILSDKG 125
            .:.||.||.       ||..:..|::     .:.:...|.|        :::|.:...|:|.|..
  Fly    78 SINHIVVPMSAEDEKVLNDGMAGMVKEKPSIWNTMKSIFSS--------LALLIDKQVDVLEDPR 134

  Fly   126 VQKMLQNRNERFDLVML------EPSALEALYGVVEHYNATLMGFSGGNVNWS------TEEVAG 178
            .|::..|:..:||:|.:      ...||.|      .:|..::      ::||      ..||.|
  Fly   135 FQELYLNKGNKFDVVFVGFFFNTYQVALGA------RFNCPVI------ISWSGPPMMMVNEVLG 187

  Fly   179 --------------------NFAPSINDPISSLGYSRSNSLLSKIYNWVHITEEKLLKHLIFRPS 223
                                ||...:.:..|:||::..|..|:..||
  Fly   188 NPELSSVPQMHISAPPGQPMNFQQRMQNFASTLGFNALNIFLNHKYN------------------ 234

  Fly   224 QLRIFKKFFN--FSEQK----FYNMREKYSVILVNNH-ISMGRVRSNVPNIIEVGGLHLTEPAEP 281
                  ||::  :|:.|    |...:...|:...|.| ||.|.:|.|||.:||:||:.:....:|
  Fly   235 ------KFYDRLWSKDKSMPTFAQAKRNVSLAFCNGHGISEGPIRPNVPGVIEIGGIQVKSKPDP 293

  Fly   282 CDSKLQKFMDDAEHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVVWKTE-LYNMPNKSDN 345
            ....:|:|::..:||.|.||:|..:..:.:..::.:.:.|.|...||:|:||.| ..|.|.||.|
  Fly   294 LPEDIQEFLEKGKHGAILFSLGSNLKGEHIQPEVVKTIFKGLSSLKQQVIWKWEDPKNTPGKSAN 358

  Fly   346 VYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEVL 410
            :...:..||..:||||..:||||:.|...|.||.|.|||:|.||||.||..|...:...|....|
  Fly   359 ILYKKWLPQDDILAHPKLKLFITHAGKGGVAEAQYHGVPMLALPVFADQPGNADKLVASGYGLQL 423

  Fly   411 DANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASHMR--- 472
            ....:.::...:.|::::|||:||...|..||.:||||:||.::.|:||||.:|:..|:||:
  Fly   424 PLATLDVDEFKAAIKEVIENPKYAKTLKSFSQLYRDRPLSPQESVVYWTEYVIRHHGAAHMQSPL 488

  Fly   473 -----LNTEDVPLYYEWDWGLLLGLRFGIVFGSVIYLVY------------KLFQKTS 513
                 :.:.::.:|              |:...|:|:|:            |||.|::
  Fly   489 VHMNFIASNNLDIY--------------IIAALVLYIVFIINKIVWKFVWRKLFGKSN 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	147/509 (29%)
Ugt37D1	NP_001285989.1	egt	25..512	CDD:223071	151/544 (28%)
Ugt37D1	NP_001285989.1	UDPGT	45..530	CDD:278624	148/542 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445698
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950