DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B3 and Ugt302C1

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	164/514 - (31%)
Similarity:	280/514 - (54%)	Gaps:	42/514 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLFCLFLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITPVGMPTDIEGV 74
            :||||.       ..|.|.|.|.:......||..|...|||.|...||.||:|:|..:...|:.:
  Fly    14 LLFCLL-------SCVSAYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFELKKPIKNI 71

  Fly    75 RHI-----------RVPKLNQRVQEMIEGDQILDFFGSKWIASLMVVSMLYNMSSDILSDKGVQK 128
            :.:           |:..|.|..:|.|. .||::|.           .|...::..:|.:..|.:
  Fly    72 KDVPAKSILTSMQGRIANLLQSSKEPII-KQIINFH-----------EMGIEITELLLKEPSVIE 124

  Fly   129 MLQNRNERFDLVMLEPSALEALYGVVEHYNATLMGF-SGGNVNWSTEEVAGNFAPSINDPISSLG 192
            :::: |:.||.|:.|....||.:|..||:.|.|:|. :.|.::|:| ::.|:.:|....|.:.|.
  Fly   125 LMKS-NQTFDAVISEVFLNEAHFGFAEHFKAPLIGLGTFGAISWNT-DLVGSPSPPSYVPSALLK 187

  Fly   193 YSRSNSLLSKIYNWVHITEEKLLKHLIFRPSQLRIFKKFFNFSEQKFYNMREKYSVILVNNHISM 257
            :|...||:.::.|...:|.|.:..:..:.|.|..:::|:|..::|.||:||:..:::|:|.|:|:
  Fly   188 FSDRMSLVERVGNQAFLTYEYIFLNYFYLPRQEVLYRKYFPNNKQDFYDMRKNTALVLLNQHVSL 252

  Fly   258 GRVRSNVPNIIEVGGLHLTEPAEPCDSKLQKFMDDAEHGVIYFSMGQEIMVQFLPEDMQQNLMKS 322
            ...|...||:|||||:|:....:|....:.:|::.|||||||||||..:..:.||.:.:|.|:.:
  Fly   253 SFPRPYSPNMIEVGGMHINRKRQPLPKDILEFIEGAEHGVIYFSMGSNLKSKTLPLEKRQALIDT 317

  Fly   323 LDQFKQRVVWKTELYNMPNKSDNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILG 387
            ..|.||||:||.|..::|.|..||::.:..||..:|||.|...|||:|||||..|::|...|.:|
  Fly   318 FAQLKQRVLWKFEDTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLSTTESIYHRKPFVG 382

  Fly   388 LPVFFDQFINLRNVNLRGMAEVLDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPL 452
            :|:|.|||:|:......|....:...|::...|.:.|:|::.||....:.:.||..:||:..:||
  Fly   383 IPIFGDQFLNMARAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDMSDRYRDQQQTPL 447

  Fly   453 DTAVWWTEYALRNKDASHMRLNTEDVPL--YYEWDWGLLLGLRFGIVFGSVIYLVYKLF 509
            :.||:|.|:..|:|.|.::|..::|:..  |:..|..|:|       :|.:|:::|.:|
  Fly   448 ERAVYWVEHVSRHKGAKYLRSASQDLNFIQYHNLDAMLIL-------YGGIIFVLYCIF 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	152/467 (33%)
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	123/350 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445610
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.800