DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B3 and Ugt35E2

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	164/541 - (30%)
Similarity:	277/541 - (51%)	Gaps:	49/541 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LAVLFCLFLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITPVGMPTDIE 72
            :.||..:.|...|....::.|.|||:|.....||.....|..|.|...||.:|.::|..:...:.
  Fly     5 MLVLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPLKEPVA 69

  Fly    73 GVRHIRVPKLNQRVQEMIEGDQILDFFGSKWIASLMVVSMLYNMSSDILSDKGVQK-MLQNRNER 136
            .:..|.||:|...::|::  ..:.:..|: |.....:......:...:|.:.||:: :||..:.:
  Fly    70 NIHDIPVPELFDNIEEIV--GNLTNRKGT-WNEFEYINQYTLGLVEKVLENDGVRREILQPESLQ 131

  Fly   137 FDLVMLEPSALEALYGVVEHYNATLMGFSGGNVNWSTEEVAGNFAPSINDPISSLGYSRSNSLLS 201
            |||::::...|:||||:..:::|.::|.:....:|..:|:.||.:|        |.|.:|.|
  Fly   132 FDLIIVDLWRLDALYGLAAYFDAPIIGIASYGTDWKIDELVGNVSP--------LAYLQSPS--- 185

  Fly   202 KIYNWV----------HITEEKLL---KHLIFRPSQLRIFKKFFN--FSEQKFYNMREKYSVILV 251
              :||.          |..::.:.   .|.........:::|:|.  ..::....:...:::|||
  Fly   186 --FNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYFPKIADKRSLSEITRNFALILV 248

  Fly   252 NNHISMGRVRSNVPNIIEVGGLHLTEPAEPCDSKLQKFMDDA-EHGVIYFSMGQEIMVQFLPEDM 315
            |.|.:|...|..|||||||||:|:.:..:.....|:.|:..| ||||||||:|..:..:.|.:|.
  Fly   249 NQHFTMAPPRPYVPNIIEVGGMHVDQQPKALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSKDR 313

  Fly   316 QQNLMKSLDQFKQRVVWKTELYNMPNKSDNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVY 380
            ::.|:.:.....||::||.:...:.:...||.:....||:.:|||||.:||||:|||.|.:|.::
  Fly   314 RKILIDTFASLPQRILWKFDADELSDVPSNVLISPWFPQQDILAHPNVKLFITHGGLQSTVECIH 378

  Fly   381 SGVPILGLPVFFDQFINLRNVNLRGMAEVLDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFR 445
            .|||:||||.|:|||.|:.::..:|:..||:..:||.:....||.:||....:.:|||:.:..:|
  Fly   379 RGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKRTADRYR 443

  Fly   446 DRPMSPLDTAVWWTEYALRNKDASHMRL--NTEDVPLYYEWD---------WGLLLGLRFGIVFG 499
            |:||:|||||:|||.|.||:|.|.|||:  ...|...|:..|         |.:|     .||..
  Fly   444 DQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAIL-----SIVVL 503

  Fly   500 SVIYLVYKLFQKTSARRRPFQ 520
            ..|.|:..:.:.......|.|
  Fly   504 CAIKLLRAILKSKKGNISPKQ 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	148/474 (31%)
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	150/473 (32%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	128/429 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445593
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.800