DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B3 and RGD1559459

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	XP_003751392.1	Gene:	RGD1559459 / 501907	RGDID:	1559459	Length:	530	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	144/560 - (25%)
Similarity:	249/560 - (44%)	Gaps:	99/560 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LFLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITP-------------- 64
            |.|...::..|.....:| ::...| ||.|.::.:...|||:||.|.::.|
  Rat    10 LLLHLTIFFGSGSGGKVL-VWPVEF-SHWLNLKIILSELVKKGHEVVVLKPSVSFSYEVDKTSAI 72

  Fly    65 --VGMPT--DIEGVRHIRVPKLNQRVQEMIEGDQILDFFGSKWIASLMVVSMLYNMSSD----IL 121
              ...|:  .|..|..|.:..:|:.:.|:.:    ..|:|     ..:::..|:..:||    :.
  Rat    73 EFESFPSSYSIADVEVIFMDCVNESIYELPK----QSFWG-----YFLMLQKLFERTSDYSERLC 128

  Fly   122 SDKGVQKMLQNR--NERFDLVMLEPSA-----------LEALYGVVEHYNATLMGFSGGNVNWST 173
            .|....|.|..:  |..||:::.:|..           :..:|.:.....:|...:|||..
  Rat   129 RDAAFNKELMTKLQNSGFDVILADPFTPCGDLLAEILKIPLVYSLRFFPGSTYEKYSGGLP---- 189

  Fly   174 EEVAGNFAPSINDPISSLGYSRSNSLLSKIYN---------WVHITEEK----LLKHLIFRPSQL 225
                   .|....||:....|...:.:.::.:         |..:.:||    |...::.||:.|
  Rat   190 -------MPPSYVPIAMSELSDRMTFVERVKHMIYVLCFDFWFQVFDEKKWNELYTEVLGRPTTL 247

  Fly   226 RIFKKFFNFSEQKFYNMREKYSVILVNNHISMGRVRSNVPNIIEVGGLHLTEPAEPCDSKLQKFM 290
                     ||     ...|..:.|:..:..:......:||...||||| ..||:|...:::.|:
  Rat   248 ---------SE-----TMAKADIWLIRTYWDLEFPHPVLPNFDFVGGLH-CRPAKPLPKEIEDFV 297

  Fly   291 DDA-EHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVVWKTELYNMPNKSDNVYVIEQPPQ 354
            ..: ||||:.||:|.  ||..|.|:....:...|.|..|:|:|:.|.........|..:.:..||
  Rat   298 QSSGEHGVVVFSLGS--MVGSLTEERANVIAAGLAQIPQKVLWRFEGKKPETLGSNTRLYKWIPQ 360

  Fly   355 RAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEVLDANEMTLEI 419
            ..:|.||.||.|||:||...:.||:|.|:|::|:|:|.||..|:.::..:|.|..||...|:...
  Rat   361 NDLLGHPKTRAFITHGGTNGIYEAIYHGIPVVGIPLFGDQKDNIVHLKTKGAAVRLDFLTMSSTD 425

  Fly   420 LTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASHMRLNTEDVP--LYY 482
            |.:.:|.:..:|.|...|.::|:...|:|:.|||.||:|.|:.:|:|.|.|:|:...|:.  .|:
  Rat   426 LLTALRTVTNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAGHDLSWVQYH 490

  Fly   483 EWDWGLLLGLRFGIVFGSVIYLVYK--LF--QK-TSARRR 517
            ..|   ::|.....|. :|::::.|  ||  || |.|.|:
  Rat   491 SLD---VIGFLLACVV-TVMFILKKCCLFCCQKFTKAGRK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	126/500 (25%)
RGD1559459	XP_003751392.1	UDPGT	24..527	CDD:278624	141/546 (26%)
RGD1559459	XP_003751392.1	egt	<270..508	CDD:223071	83/244 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344089
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.640